NEW MATERIAL:A compound expressed by formula I or acid-added salt of said compound (for R2a and R3a are simultaneously H, -Xa-R1a is n-butyl, cyclohexyl or benzyl, etc.; R2a is H and -Xa-R1a is benzyl and R3a is methyl, or -Xa-R1a and R3a and simultaneously phenyl; R3a is H and -Xa-R1a and R2a are ethyl, -Xa-R1a and R2a are n-butyl, or -Xa-R1a is benzyl and R2a, etc.; etc.).
EXAMPLE: 1-amino-3-benzylguanidine.
USE: Inhibitor of Maillard reaction. Useful for remedy of various complication of diabetes mellitus or disease induced by senescence, etc.
PREPARATION: A compound expressed by formula II is reacted with a compound expressed by the formula R3a-NHNH2 in water or alkanol at room temperature, or a compound expressed by formula III is reacted with ammonia in water with refluxing in the presence of ammonium sulfate to obtain the compound expressed by formula I.
TODA MASAAKI
MIYAMOTO TSUMORU
