Title:
ソルビトールデヒドロゲナーゼ阻害薬としてのアミノピリミジン
Document Type and Number:
Japanese Patent JP3581103
Kind Code:
B2
Abstract:
This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.
Inventors:
Chumoyer, Margaret Yuhua
Mari, Jerry Anthony
Bairnara Lakshman, Mailari
Zenbrowski, William James
Mari, Jerry Anthony
Bairnara Lakshman, Mailari
Zenbrowski, William James
Application Number:
JP2000609073A
Publication Date:
October 27, 2004
Filing Date:
March 16, 2000
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
A61K31/505; A61K31/506; A61K31/517; A61K31/53; A61K31/5377; A61P3/10; A61P9/10; A61P43/00; C07D239/42; C07D241/44; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D417/12; C07D417/14; C07D451/02; C07D451/06; C07D451/14; C07D471/04; C07D471/08; C07D487/04; C07D487/08; C07D491/04; C07D491/048; C07D491/10; C07D491/20; C07D498/04; C07D513/10; C07D521/00; (IPC1-7): C07D239/42; A61K31/506; A61K31/517; A61K31/53; A61K31/5377; A61P3/10; A61P9/10; A61P43/00; C07D401/04; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D417/12; C07D417/14; C07D471/04; C07D471/08; C07D487/04; C07D491/048; C07D491/20; C07D498/04; C07D513/10
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Hisako Nozaki
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Hisako Nozaki