Title:
AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS
Document Type and Number:
Japanese Patent JP2022185107
Kind Code:
A
Abstract:
To provide aminothiazole compounds as C-KIT inhibitors.SOLUTION: The present invention relates to c-Kit inhibitors useful in the treatment of cancers and other serine-threonine kinase mediated diseases, which have the formula in the figure, where A, L, R1, R2, R3 and n are described herein. The present invention is directed to inhibitors of tyrosine-protein kinase Kit (c-Kit) useful in the treatment of diseases or disorders associated with c-Kit. Specifically, the invention is concerned with compounds and compositions inhibiting c-Kit, methods of treating diseases or disorders associated with c-Kit, and methods of synthesis of these compounds.SELECTED DRAWING: None
Inventors:
NICHOLAS E BENCIVENGA
DAVID C DALGARNO
JOSEPH M GOZGIT
HUANG WEI-SHENG
ANNA KOHLMANN
LI FENG
QI JIWEI
WILLIAM C SHAKESPEARE
RANNY M THOMAS
WANG YIHAN
ZHU XIAOTIAN
DAVID C DALGARNO
JOSEPH M GOZGIT
HUANG WEI-SHENG
ANNA KOHLMANN
LI FENG
QI JIWEI
WILLIAM C SHAKESPEARE
RANNY M THOMAS
WANG YIHAN
ZHU XIAOTIAN
Application Number:
JP2022163177A
Publication Date:
December 13, 2022
Filing Date:
October 11, 2022
Export Citation:
Assignee:
ARIAD PHARMA INC
International Classes:
C07D277/44; A61K31/426; A61K31/427; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/5377; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/08; A61P43/00; C07D417/12; C07D417/14
Domestic Patent References:
| JP2009536652A | 2009-10-15 |
Foreign References:
| WO2015108490A2 | 2015-07-23 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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