器官特異的薬物ターゲティング用両親媒性化合物及び小胞/リポソーム

Japanese Patent JP2005521645

A

An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.

Heldman, Eliahu
Lindale, Charles
Grinburg, Salina
Koroto, Victoria
Shoubi, Eleonora

JP2003548760A

July 21, 2005

December 04, 2002

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Ben Gurion University of the Nejeb Research and Development Authority

A61K9/127; A61K31/137; A61K31/197; A61K31/198; A61K31/27; A61K31/4425; A61K31/473; A61K31/704; A61K38/00; A61K38/28; A61K39/395; A61K45/00; A61K47/16; A61K47/18; A61K47/22; A61K47/28; A61K47/42; A61K48/00; A61K49/00; A61P3/10; A61P25/16; A61P25/28; A61P29/00; C07C219/06; C07C229/12; C07C233/36; C07C235/28; C07C237/10; C07D303/46; C07D401/04; C07H7/00; C07H15/26; (IPC1-7): C07C219/06; A61K9/127; A61K31/137; A61K31/197; A61K31/198; A61K31/27; A61K31/4425; A61K31/473; A61K31/704; A61K38/00; A61K38/28; A61K39/395; A61K45/00; A61K47/16; A61K47/18; A61K47/22; A61K47/28; A61K47/42; A61K48/00; A61K49/00; A61P3/10; A61P25/16; A61P25/28; A61P29/00; C07C229/12; C07C233/36; C07C235/28; C07C237/10; C07D303/46; C07D401/04

Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda

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