Title:
AMPHIPHILIC POLY(N-VINYL-2-PYRROLIDONE) COPOLYMER
Document Type and Number:
Japanese Patent JP2012229433
Kind Code:
A
Abstract:
To prepare a block copolymer of a drug delivery system by forming a stabilized radical of poly(N-vinyl-2-pyrrolidone).
In a two-step polymerization method, poly(N-vinylpyrrolidone) having a hydroxy terminal is prepared, and then other diblock and triblock copolymers are prepared. The block copolymers can be used as vehicles for drug delivery.
Inventors:
LUO LAIBIN
LESSARD DAVID
GORI SANDRA
RANGER MAXIME
WANG YUAN
LAFRENIERE JULIE
MEUNIER JEAN-FRANCOIS
BIBEAU GENEVIEVE
LEBRUN FREDERIC
LIU LU WEI
LESSARD DAVID
GORI SANDRA
RANGER MAXIME
WANG YUAN
LAFRENIERE JULIE
MEUNIER JEAN-FRANCOIS
BIBEAU GENEVIEVE
LEBRUN FREDERIC
LIU LU WEI
Application Number:
JP2012155119A
Publication Date:
November 22, 2012
Filing Date:
July 11, 2012
Export Citation:
Assignee:
LABOPHARM INC
International Classes:
C08G63/08; C08F8/00; C08F26/10; C08F126/10; C08F265/04; C08F293/00; C08F297/00; C08F297/02; C08K5/05; C08L53/00
Domestic Patent References:
| JPH08510278A | 1996-10-29 |
Other References:
JPN6013038033; Ｌ． Ｌｕｏ ｅｔ ａｌ: 'Ｎｏｖｅｌ Ａｍｐｈｉｐｈｉｌｉｃ Ｄｉｂｌｏｃｋ Ｃｏｐｏｌｙｍｅｒ ｏｆ Ｌｏｗ Ｍｏｌｅｃｕｌａｒ Ｗｅｉｇｈｔ Ｐｏｌｙ（Ｎ-ｖｉｎｙｌｐｙｒｒｏｌｉｄｏｎｅ）-ｂｌｏｃｋ-ｐｏｌｙ（Ｄ，Ｌ-' Ｍａｃｒｏｍｏｌｅｃｕｌｅｓ Ｖｏｌ．３７, 2004, ４００８-４０１３, Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ
JPN6013038032; Ａ． Ｂｅｎａｈｍｅｄ， Ｍ． Ｒａｎｇｅｒ， ａｎｄ Ｊ．-Ｃ． Ｌｅｒｏｕｘ: 'Ｎｏｖｅｌ Ｐｏｌｙｍｅｒｉｃ Ｍｉｃｅｌｌｅｓ Ｂａｓｅｄ ｏｎ ｔｈｅ Ａｍｐｈｉｐｈｉｌｉｃ Ｄｉｂｌｏｃｋ Ｃｏｐｏｌｙｍｅｒ Ｐｏｌｙ（Ｎ-ｖｉｎｙｌ-２-ｐｙｒｒｏｌｉｄｏｎｅ）-ｂｌｏｃ' Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１８， Ｎｏ．３, 200103, ３２３-３２８, Ｐｌｅｎｕｍ Ｐｕｂｌｉｓｈｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ
JPN6013038032; Ａ． Ｂｅｎａｈｍｅｄ， Ｍ． Ｒａｎｇｅｒ， ａｎｄ Ｊ．-Ｃ． Ｌｅｒｏｕｘ: 'Ｎｏｖｅｌ Ｐｏｌｙｍｅｒｉｃ Ｍｉｃｅｌｌｅｓ Ｂａｓｅｄ ｏｎ ｔｈｅ Ａｍｐｈｉｐｈｉｌｉｃ Ｄｉｂｌｏｃｋ Ｃｏｐｏｌｙｍｅｒ Ｐｏｌｙ（Ｎ-ｖｉｎｙｌ-２-ｐｙｒｒｏｌｉｄｏｎｅ）-ｂｌｏｃ' Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１８， Ｎｏ．３, 200103, ３２３-３２８, Ｐｌｅｎｕｍ Ｐｕｂｌｉｓｈｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ
Attorney, Agent or Firm:
Masahiro Abe
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