Title:
Amyloid beta neuropathy biomarker
Document Type and Number:
Japanese Patent JP5907563
Kind Code:
B2
Abstract:
A novel biomarker for diagnosing amyloid ² -related neuropathy such as Alzheimer's disease is provided. Disclosed is a method for diagnosing Alzheimer's disease comprising measuring the level of a MFG-E8 protein in a blood, serum or plasma sample obtained from a human or animal subject, wherein the measured value is used as a marker for diagnosis of Alzheimer's disease. The MFG-E8 protein is found to bind to phosphatidylserine in a Ca 2+ dependent manner in a culture supernatant of mouse brain nerve cells, which are a dementia model stimulated with A ² 42 . It is also found that the level of the MFG-E8 protein is increased in patients with Alzheimer's disease.
Inventors:
Yasuo Koumi
Hitoshi Soma
Shinichi Imai
Keiyo Matsumoto
Kimura Shigetoshi
Hitoshi Soma
Shinichi Imai
Keiyo Matsumoto
Kimura Shigetoshi
Application Number:
JP2012548738A
Publication Date:
April 26, 2016
Filing Date:
December 05, 2011
Export Citation:
Assignee:
Hokkaido Public University Corporation Sapporo Medical University
International Classes:
G01N33/15; G01N33/53; G01N33/50
Other References:
JPN6011068095; Ｂｏｄｄａｅｒｔ Ｊ． ｅｔ ａｌ．: 'Ｅｖｉｄｅｎｃｅ ｏｆ ａ ｒｏｌｅ ｆｏｒ ｌａｃｔａｄｈｅｒｉｎ ｉｎ Ａｌｚｈｅｉｍｅｒ'ｓ ｄｉｓｅａｓｅ．' Ａｍ．Ｊ．Ｐａｔｈｏｌ． Ｖｏｌ．１７０（３）, 2007, ｐ．９２１-９２９
Attorney, Agent or Firm:
Seiji Ohno
Keiko Kanemoto
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Umeda Shinsuke
Keiko Kanemoto
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Umeda Shinsuke
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