Title:
癌治療に使用するベンゾキノン包含アンサマイシン類のアナログ
Document Type and Number:
Japanese Patent JP4869077
Kind Code:
B2
Abstract:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer (formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)-ammonium hydroquinone ansamycin analog.
Inventors:
Adams, Julian
Gao, Yun
Georges Evangelinos, Asymina Tea
Glenier, Lewis
Park, Roger H
Porter, james are
Light, james ell
Gao, Yun
Georges Evangelinos, Asymina Tea
Glenier, Lewis
Park, Roger H
Porter, james are
Light, james ell
Application Number:
JP2006547323A
Publication Date:
February 01, 2012
Filing Date:
December 23, 2004
Export Citation:
Assignee:
INFINITY INC
International Classes:
C07D225/06; A61K31/395; A61K31/424; A61K31/5386; A61K47/02; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/22; A61K47/24; A61K47/34; A61K47/40; A61K47/44; A61P35/00; A61P35/02; C07D211/60; C07D403/14; C07D498/08; C07F5/02; C07F9/6561
Domestic Patent References:
| JP6510913A |
Foreign References:
| WO2003066005A1 | ||||
| WO2003013430A1 | ||||
| WO1995001342A1 | ||||
| GB210611A |
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma