Title:
ANALYSIS OF GENOMIC DNA, RNA, AND PROTEINS IN EXOSOMES FOR DIAGNOSIS AND THERAPY
Document Type and Number:
Japanese Patent JP2019198327
Kind Code:
A
Abstract:
To provide analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and therapy.SOLUTION: Provided are exosomes derived from human body fluid samples that contain double stranded genomic DNA that spans all chromosomes and can be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.SELECTED DRAWING: None
Inventors:
RAGHU KALLURI
SONIA MELO
SONIA MELO
Application Number:
JP2019148579A
Publication Date:
November 21, 2019
Filing Date:
August 13, 2019
Export Citation:
Assignee:
UNIV TEXAS
International Classes:
C12N15/09; A61K38/17; A61K47/42; A61K47/44; A61K48/00; A61P35/00; A61P43/00; C07K14/435; C12N5/071; C12N15/12; C12P21/02; C12Q1/06; C12Q1/6806; C12Q1/6851; C12Q1/686; C12Q1/6869; G01N33/50; G01N33/68
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita