Title:
アンドロゲン受容体調節カルボキシアミド
Document Type and Number:
Japanese Patent JP2014511895
Kind Code:
A
Abstract:
Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14′, R15, R15′, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.
Inventors:
Terme Cangas, Orli
Ballfart, Gerd
Salo, Harri
Lamas Bramanian, Ratuna Durga
Patra, Pranab Kumar
Martin, Alptaraj Eveniza
Heikkinen, Telhi
Besalainen, Anne Nina
Moulinen, Anu
Kalyainen, Alya
Ballfart, Gerd
Salo, Harri
Lamas Bramanian, Ratuna Durga
Patra, Pranab Kumar
Martin, Alptaraj Eveniza
Heikkinen, Telhi
Besalainen, Anne Nina
Moulinen, Anu
Kalyainen, Alya
Application Number:
JP2014505683A
Publication Date:
May 19, 2014
Filing Date:
April 20, 2012
Export Citation:
Assignee:
Orion Corporation
International Classes:
C07D231/14; A61K31/4155; A61K31/4162; A61K31/4178; A61K31/422; A61K31/4245; A61K31/429; A61K31/437; A61K31/4439; A61K31/497; A61K31/519; A61P35/00; A61P43/00; C07D401/14; C07D403/12; C07D403/14; C07D413/12; C07D471/04; C07D487/04; C07D513/04
Foreign References:
| WO2011051540A1 | 2011-05-05 | |||
| WO2008124000A2 | 2008-10-16 | |||
| WO2010032200A1 | 2010-03-25 | |||
| WO2009028543A1 | 2009-03-05 | |||
| WO2003051358A1 | 2003-06-26 | |||
| WO2011051540A1 | 2011-05-05 | |||
| WO2008124000A2 | 2008-10-16 | |||
| WO2010032200A1 | 2010-03-25 | |||
| WO2009028543A1 | 2009-03-05 | |||
| WO2003051358A1 | 2003-06-26 |
Attorney, Agent or Firm:
Kawamura Taku
Yousuke Fujimori
Masahiro Mishima
Yousuke Fujimori
Masahiro Mishima