Title:
アンドロゲン受容体調節剤としてのアンドロスタン類
Document Type and Number:
Japanese Patent JP2005507886
Kind Code:
A
Abstract:
Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating a function of the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of activating the function of the androgen receptor in a patient, and in particular the method wherein the function of the androgen receptor is blocked in the prostate of a male patient or in the uterus of a female patient and activated in bone and/or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteopenia, osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, female sexual dysfunction, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, prostate cancer, inflammatory arthritis and joint repair, alone or in combination with other active agents.
Inventors:
One, Chiapin
Application Number:
JP2003530207A
Publication Date:
March 24, 2005
Filing Date:
September 17, 2002
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
A61K45/00; A61K31/568; A61K31/5685; A61K31/569; A61K31/58; A61K31/663; A61K45/06; A61P1/02; A61P1/14; A61P3/06; A61P5/26; A61P7/00; A61P7/06; A61P9/10; A61P15/00; A61P15/08; A61P15/10; A61P15/12; A61P17/00; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P29/00; A61P31/18; A61P35/00; A61P37/00; A61P43/00; C07J1/00; C07J41/00; C07J43/00; (IPC1-7): A61K31/568; A61K45/00; A61P1/02; A61P1/14; A61P3/06; A61P5/26; A61P7/00; A61P7/06; A61P9/10; A61P15/00; A61P15/08; A61P15/10; A61P15/12; A61P17/00; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P29/00; A61P31/18; A61P35/00; A61P37/00; A61P43/00; C07J1/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura