Title:
血管形成阻害分子、並びに癌の治療及び診断におけるその使用
Document Type and Number:
Japanese Patent JP2007515159
Kind Code:
A
Abstract:
The present invention relates to a method for providing molecules that are capable of inhibiting angiogenesis, comprising the steps of providing a range of molecules; testing whether these molecules can prevent interaction between JAM-B and JAM-C; testing the positive molecules for their ability to block angiogenesis in vivo; and selecting molecules that are positive in the angiogenesis test as angiogenesis inhibiting molecules. The method may further comprise the step of isolating or producing the angiogenesis inhibiting molecules. The invention further relates to the angiogenesis inhibiting molecules thus provided and produced, to their use in the treatment of cancer, to therapeutical and diagnostic compositions comprising them. In a particular embodiment the invention relates to monoclonal antibodies, in particular MAb H33, to soluble JAM-C and JAM-B and to small molecules.
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Inventors:
Imhoff, Beat, Albert
Orlando-Rion, Michelle
Orlando-Rion, Michelle
Application Number:
JP2006540362A
Publication Date:
June 14, 2007
Filing Date:
November 19, 2004
Export Citation:
Assignee:
Laboratories Serono S.A.
International Classes:
C12N15/09; A61K38/17; A61K39/395; A61P9/00; A61P35/00; C07K14/705; C07K16/18; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N5/20; C12P21/08; G01N33/531; G01N33/566; G01N33/574; C12R1/01; C12R1/645
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio