アンジオスタチンおよび血管形成の抑制におけるその使用

Title:

アンジオスタチンおよび血管形成の抑制におけるその使用

Document Type and Number:

Japanese Patent JP3880064

Kind Code:

B2

Abstract:

The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial inhibitor is a protein isolated from the blood or urine that is eluted as a single peak from C4-reverse phase high performance liquid chromatography. The endothelial inhibitor is a molecule comprising a protein having a molecular weight of between approximately 38 kilodaltons and 45 kilodaltons as determined by reducing polyacrylamide gel electrophoresis and having an amino acid sequence substantially similar to that of a murine plasminogen fragment beginning at amino acid number 98 of a murine plasminogen molecule.

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Inventors:

Aurey Lee, Michael, S.
Folkman, M, Juda
Sim, kim, lee
Khao, Ehi

Application Number:

JP52783195A

Publication Date:

February 14, 2007

Filing Date:

April 26, 1995

Export Citation:

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Assignee:

ABBOTT LABORATORIES

International Classes:

A61K38/00; C12N15/09; A61K35/76; A61K38/43; A61K48/00; A61P9/00; A61P27/02; A61P29/00; A61P35/00; C07H21/04; C07K14/47; C12N5/10; C12N9/68; C12N15/57; C12P21/02; C12P21/08; C12Q1/02; G01N33/15; G01N33/50; G01N33/574

Other References:

血液と脈管,Vol.17(4)(1986)p.369-73
Arch.Biochem.Biophys.,Vol.230(1)(1984)p.306-15
J.Biol.Chem.,Vol.265(11)(1990)p.6104-11

Attorney, Agent or Firm:

Hidekazu Miyoshi

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