PURPOSE: To obtain a large amount of dihydrofolic acid reductase-angiotensin II fused protein, by manifesting a fused gene in which an angiotensin II gene is included in a plasmid vector pTP 70-1 with a colon bacillus.

CONSTITUTION: A newly recombined plasmid pANG2-11, which is replicated in stable with a colon bacillus, imparting resistance to trimethoprim and resistance to ampicillin to a colon bacillus as a host, having a size of 4651 basic pairs and having a bonded structure of chemically synthesized DNA of 43 basic pairs containing a conformation coding angiotensin II at BamHI site of pTP 70-1, is produced. A colon bacillus introduced of the plasmid pANG2-11 (FERM BP-1815) produces a large amount of dihydrofolic acid reductase-angiotensin II fused protein.