Title:
ANTAGONISTIC CD40 MONOCLONAL ANTIBODIES AND USES THEREOF
Document Type and Number:
Japanese Patent JP2023106402
Kind Code:
A
Abstract:
To provide antibodies that bind CD40 but do not exhibit CD40 agonist activity, wherein the antibodies may comprise a modified IgG1 Fc domain, and exhibit minimal activation of immature dendritic cells; compositions comprising the antibodies; methods of use for treatment of diseases involving CD40 activity; and use in the preparation of a medicament for treatment of a disease involving CD40 activity.SOLUTION: The present invention provides a nucleic acid molecule encoding an isolated antibody that specifically binds to human CD40 or an antigen binding portion thereof, wherein the antibody comprises a specific sequence, comprising a first polypeptide portion comprising a heavy chain variable region and a second polypeptide portion comprising a light chain variable region.SELECTED DRAWING: None
Inventors:
AARON YAMNIUK
MARY STRUTHERS
STANLEY R KRYSTEK JR
AKBAR NAYEEM
GINGER RAKESTRAW
MARY STRUTHERS
STANLEY R KRYSTEK JR
AKBAR NAYEEM
GINGER RAKESTRAW
Application Number:
JP2023072027A
Publication Date:
August 01, 2023
Filing Date:
April 26, 2023
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
C12N15/13; A61K9/08; A61K39/395; A61K47/02; A61K47/10; A61K47/36; A61P1/02; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P5/16; A61P5/38; A61P7/04; A61P7/06; A61P9/00; A61P9/10; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P37/02; A61P37/06; A61P37/08; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08
Attorney, Agent or Firm:
Norito Yamao
Norifumi Tomita
Fumio Inai
Manami Sasakura
Norifumi Tomita
Fumio Inai
Manami Sasakura
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