Title:
アントラニルアミド誘導体およびそれを含有するＴＬＲ３が関与する疾患の治療剤
Document Type and Number:
Japanese Patent JP6750177
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a low molecular organic compound having excellent Toll-like receptor (TLR) 3 activity inhibitory action.SOLUTION: The present invention provides an anthranilamide derivative represented by formula 1 or pharmaceutically acceptable salt thereof [Ris substituted/unsubstituted alkyl, substituted/unsubstituted alkenyl or the like; Ris substituted/unsubstituted alkyl or substituted/unsubstituted aryl; R is H or alkyl; Qis N or CR. Qis N or CR. Rand R, Rand Rare H, a halogen atom, cyano, optionally substituted alkyl, and the like].SELECTED DRAWING: Figure 1
Inventors:
Kyoko Okuno
Kinoshita Shigeru
Ichiro Tsuchuro
Mayumi Ueda
Kinoshita Shigeru
Ichiro Tsuchuro
Mayumi Ueda
Application Number:
JP2016074085A
Publication Date:
September 02, 2020
Filing Date:
April 01, 2016
Export Citation:
Assignee:
Rohto Pharmaceutical Co., Ltd.
International Classes:
C07C237/42; A61K31/167; A61K31/335; A61K31/351; A61K31/44; A61P29/00; A61P31/00; A61P35/00; A61P37/00; A61P43/00; C07C237/44; C07D213/81; C07D309/04; C07D321/10
Domestic Patent References:
| JP8188563A | ||||
| JP2011516577A | ||||
| JP2012503607A | ||||
| JP2008517061A | ||||
| JP10259129A | ||||
| JP10259176A | ||||
| JP2005535710A | ||||
| JP2005514324A | ||||
| JP2014148491A | ||||
| JP2007524615A |
Foreign References:
| WO1997038684A1 | ||||
| WO2014052605A1 | ||||
| WO2013165606A1 | ||||
| WO2011155898A1 | ||||
| WO2011035159A1 | ||||
| WO2008131481A1 | ||||
| KR1020140134568A | ||||
| CN103539694A | ||||
| WO2013108837A1 |
Other References:
Chemical Communications (Cambridge, United Kingdom) ,2015年,51(56),p.11178-11181
Letters in Drug Design & Discovery,2015年,12(3),p.190-205
Journal of the Royal Society, Interface,2012年,9(77),p.3196-3207
Helvetica Chimica Acta ,2010年,93(12),p.2365-2392
Pharmaceutical Chemistry Journal,2008年,42(12),p.674-676
Bioorganic & Medicinal Chemistry Letters,2008年,18(9),p.2990-2995
Egyptian Journal of Chemistry,1980年,Volume Date 1978,21(2),p.115-131
Farmaco, Edizione Scientifica,1970年,25(12),p.991-998
Journal of the Chemical Society [Section] C: Organic,1966年,(24),p.2290-2295
Letters in Drug Design & Discovery,2015年,12(3),p.190-205
Journal of the Royal Society, Interface,2012年,9(77),p.3196-3207
Helvetica Chimica Acta ,2010年,93(12),p.2365-2392
Pharmaceutical Chemistry Journal,2008年,42(12),p.674-676
Bioorganic & Medicinal Chemistry Letters,2008年,18(9),p.2990-2995
Egyptian Journal of Chemistry,1980年,Volume Date 1978,21(2),p.115-131
Farmaco, Edizione Scientifica,1970年,25(12),p.991-998
Journal of the Chemical Society [Section] C: Organic,1966年,(24),p.2290-2295
Attorney, Agent or Firm:
Tomohiro Sakamoto