PURPOSE: To obtain a new anthrapyrazole compound useful as an antitumor agent having excellent antitumor activity and low toxicity.
CONSTITUTION: A compound of the formula [R1 and R2 are each H, OH, an alkyl, a hydroxyalkyl, an alkoxyalkyl, an alkenyl, a hydroxyalkenyl, an alkoxyalkenyl or an acyl (with the proviso that a case wherein both R1 and R2 are H or OH at the same time or one of R1 and R2 is H and the other is OH is omitted); R3 and R4 are each an alkyl, a hydroxyalkyl, an alkoxyalkyl, (CH2)n-NR5R6 (R5 and R6 are each H, an alkyl, a hydroxyalkyl, an alkoxyalkyl, an aminoalkyl or a primary or a secondary alkylaminoalkyl; (n) is 1-6)] such as 10-ethyl-7-hydroxy-2-[(2-hydroxyethyl)amino]ethyl]-5-methylaminoanthra[1,9- cd]pyrazoto-6(2H)-one.
YUNOU TAKEO
ITO YUKIYASU
MANABE SHUNICHI