ANTHRAQUINONE ANALOG AND METHOD OF MAKING AND USING THEREOF

Japanese Patent JP2018154659

A

PROBLEM TO BE SOLVED: To provide anthraquinone analogs and methods of making and using thereof.SOLUTION: Rhein analogs that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such a ring system is actuated by facilitating non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional group to improve the solubility of the compounds.SELECTED DRAWING: None

JPH07110830	[Title of Invention] Phenanthrene derivative
JP2004532833	Self-reducing anthraquinone compound
WO/2003/009807	CYTOPROTECTIVE COMPOUNDS, PHARMACEUTICAL AND COSMETIC FORMULATIONS, AND METHODS

WANG BINGHE
DAI CHAOFENG
ALEXANDER DRAGANOV
YANG XIAOCHUAN
SUN GUOJING
YANG CHUNHAO
CHEN WEIXUAN
NI NANTING
ZHOU MUXIANG
GU LUBING

JP2018120077A

October 04, 2018

June 25, 2018

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GEORGIA STATE UNIV RES FOUNDATION INC
UNIV EMORY
CHILDRENS HEATLHCARE OF ATLANTA INC

C07C50/34; A61K31/10; A61K31/122; A61K31/136; A61K31/165; A61K31/166; A61K31/167; A61K31/192; A61K31/216; A61K31/341; A61K31/381; A61K31/42; A61K31/44; A61K31/4406; A61K31/4453; A61K31/495; A61K31/5375; A61K31/655; A61P35/00; A61P35/02; A61P43/00; C07C225/36; C07C233/33; C07C235/24; C07C237/04; C07C247/12; C07C255/19; C07C311/08; C07D213/30; C07D213/70; C07D261/08; C07D295/10; C07D295/14; C07D295/15; C07D307/40; C07D333/16

Hidesaku Yamamoto
Natsuki Morishita

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