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Title:
ANTHRAQUINONE ANALOG AND METHOD OF MAKING AND USING THEREOF
Document Type and Number:
Japanese Patent JP2018154659
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide anthraquinone analogs and methods of making and using thereof.SOLUTION: Rhein analogs that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such a ring system is actuated by facilitating non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional group to improve the solubility of the compounds.SELECTED DRAWING: None

Inventors:
ビンヘ ワン
チャオフェン ダイ
アレクサンダー ドラガノフ
シャオチュアン ヤン
グオジン サン
ヤン チュンハオ
ウェイシュアン チェン
ナンティン ニ
ムシャン ゾウ
ルビン グ
Application Number:
JP2018120077A
Publication Date:
October 04, 2018
Filing Date:
June 25, 2018
Export Citation:
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Assignee:
ジョージア ステイト ユニバーシティ リサーチ ファンデーション, インコーポレイテッド
エモリー ユニバーシティー
チルドレンズ ヘルスケア オブ アトランタ, インコーポレイテッド
International Classes:
C07C50/34; A61K31/10; A61K31/122; A61K31/136; A61K31/165; A61K31/166; A61K31/167; A61K31/192; A61K31/216; A61K31/341; A61K31/381; A61K31/42; A61K31/44; A61K31/4406; A61K31/4453; A61K31/495; A61K31/5375; A61K31/655; A61P35/00; A61P35/02; A61P43/00; C07C225/36; C07C233/33; C07C235/24; C07C237/04; C07C247/12; C07C255/19; C07C311/08; C07D213/30; C07D213/70; C07D261/08; C07D295/10; C07D295/14; C07D295/15; C07D307/40; C07D333/16
Attorney, Agent or Firm:
山本 秀策
森下 夏樹