抗Ｃ５抗体および使用方法

Japanese Patent JP6755217

B2

An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the beta chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the beta chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament.

Keike Naoto
Zenjiro Sanbe

JP2017132406A

September 16, 2020

July 06, 2017

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Chugai Pharmaceutical Co., Ltd.

C12P21/08; C07K16/18; C12N15/09

JP2010521194A
JP2011529700A

WO2014119969A1

Scand.J.Immunol.,1988年,vol.28,p.307-312
The Journal of Biological Chemistry,2012年,vol.287,no.23,pp.19642-19652
Journal of Immunology,1991年,vol.146,no.1,p.362-368

Masao Haruna
Hatsushi Shimizu
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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