Anti-HLA-B * 27 antibody and its use

Japanese Patent JP6320993

B2

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind HLA-B*27 (also called HLA-B27). In certain embodiments, the antibodies of the invention bind soluble and/or cell surface-expressed forms of HLA-B*27. The antibodies of the present invention, in certain embodiments, inhibit HLA-B*27-mediated activation of T cells. Certain exemplary antibodies of the present invention exhibit enhanced binding to HLA-B*27 as compared to other HLA-B allelic variants (e.g., HLA-B*07). The present invention also provides anti-HLA-B*27 antibodies with pH-dependent binding characteristics (e.g., higher affinity binding at neutral pH than at acidic pH). The antibodies of the invention are useful for the treatment of diseases and disorders associated with HLA-B*27 expression, including ankylosing spondylitis and other spondyloarthropathies.

Andrew Jay Murphy
Ana costic

JP2015504677A

May 09, 2018

April 02, 2013

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REGENERON PHARMACEUTICALS, INC.

C07K16/18; A61K39/395; A61P1/04; A61P19/02; A61P21/00; A61P27/02; A61P37/06

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Junji Yuda
Noriyuki Takebayashi

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