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Title:
抗HS6ST2抗体及びその用途
Document Type and Number:
Japanese Patent JP5756292
Kind Code:
B2
Abstract:
The present invention provides antibodies that bind to HS6ST2 proteins, pharmaceutical compositions comprising the antibodies as active ingredients, methods for diagnosing cancer using the antibodies, HS6ST2 proteins conjugated to cytotoxic agents and pharmaceutical compositions comprising the HS6ST2 proteins as active ingredients.

Inventors:
Kawai Shigeto
Naoki Kimura
Application Number:
JP2010544062A
Publication Date:
July 29, 2015
Filing Date:
December 22, 2009
Export Citation:
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Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07K16/40; A61K39/395; A61P35/00
Other References:
JPN6010006983; HABUCHI, H., et al.: 'Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced fo' Biochem. J. vol.371, 2003, p.131-142
JPN6010006980; HABUCHI, H., et al.: 'The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificit' J. Biol. Chem. Vol.275, No.4, 2000, p.2859-2868
JPN6010006986; BACKEN, A.C., et al.: 'Heparan sulphate synthetic and editing enzymes in ovarian cancer.' Br. J. Cancer Vol.96, No.10, 2007, p.1544-1548
JPN6010006985; 三宅豪一郎, 他: 'ヘパラン硫酸-O-硫酸転移酵素群(HS2ST,HS6ST)のヒト相同遺伝子のクローニングと癌組織にお' Cancer Science Vol.91, No.Supplement, 20000901, p.145(1595)
JPN6010006983; HABUCHI, H., et al.: 'Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced fo' Biochem. J. vol.371, 2003, p.131-142
JPN6010006980; HABUCHI, H., et al.: 'The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificit' J. Biol. Chem. Vol.275, No.4, 2000, p.2859-2868
JPN6010006986; BACKEN, A.C., et al.: 'Heparan sulphate synthetic and editing enzymes in ovarian cancer.' Br. J. Cancer Vol.96, No.10, 2007, p.1544-1548
JPN6010006985; 三宅豪一郎, 他: 'ヘパラン硫酸-O-硫酸転移酵素群(HS2ST,HS6ST)のヒト相同遺伝子のクローニングと癌組織にお' Cancer Science Vol.91, No.Supplement, 20000901, p.145(1595)
JPN6010006983; HABUCHI, H., et al.: 'Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced fo' Biochem. J. vol.371, 2003, p.131-142
JPN6010006980; HABUCHI, H., et al.: 'The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificit' J. Biol. Chem. Vol.275, No.4, 2000, p.2859-2868
JPN6010006986; BACKEN, A.C., et al.: 'Heparan sulphate synthetic and editing enzymes in ovarian cancer.' Br. J. Cancer Vol.96, No.10, 2007, p.1544-1548
JPN6010006985; 三宅豪一郎, 他: 'ヘパラン硫酸-O-硫酸転移酵素群(HS2ST,HS6ST)のヒト相同遺伝子のクローニングと癌組織にお' Cancer Science Vol.91, No.Supplement, 20000901, p.145(1595)
JPN6010006983; HABUCHI, H., et al.: 'Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced fo' Biochem. J. vol.371, 2003, p.131-142
JPN6010006980; HABUCHI, H., et al.: 'The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificit' J. Biol. Chem. Vol.275, No.4, 2000, p.2859-2868
JPN6010006986; BACKEN, A.C., et al.: 'Heparan sulphate synthetic and editing enzymes in ovarian cancer.' Br. J. Cancer Vol.96, No.10, 2007, p.1544-1548
JPN6010006985; 三宅豪一郎, 他: 'ヘパラン硫酸-O-硫酸転移酵素群(HS2ST,HS6ST)のヒト相同遺伝子のクローニングと癌組織にお' Cancer Science Vol.91, No.Supplement, 20000901, p.145(1595)
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Hiroko Ejiri