Title:
Anti-NOTCH-1 antibody
Document Type and Number:
Japanese Patent JP6059985
Kind Code:
B2
Abstract:
This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the NotchI negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
Inventors:
Zdeneck Host Muskey
Angry
John Andrew Lippincott
King Hypeng
Dona Marie Stone
Ping way
Angry
John Andrew Lippincott
King Hypeng
Dona Marie Stone
Ping way
Application Number:
JP2012515616A
Publication Date:
January 11, 2017
Filing Date:
June 16, 2010
Export Citation:
Assignee:
Pfizer Inc.
Reinat Neuroscience Corporation
Reinat Neuroscience Corporation
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Foreign References:
| WO2008150525A1 |
Other References:
THE JOURNAL OF BIOLOGICAL CHEMISTRY,2008年,Vol.283,No.12,p.8046-8054
Attorney, Agent or Firm:
Noh four
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