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Title:
ANTI-ARTERIOSCLEROTIC REMEDY
Document Type and Number:
Japanese Patent JP3860849
Kind Code:
B2
Abstract:

PURPOSE: To produce an antiarteriosclerotic agent which comprises a menatetrenone derivative typified by vitamin K2 and is efficacious for arteriosclerosis and has the hypocholesteremic action in serum with high safety.
CONSTITUTION: This antiarteriosclerotic agent contains a menatetrenone derivative of the formula (the dotted line means a single or double bond) as an active ingredient. As arteriosclerosis, are cited coronary arteriosclerosis, abdominal aorta sclerosis, arteriosclerosis obliterans, renal arteriosclerosis, carotid arteriosclerosis, opthalmic arteriosclerosis and cerebral arteriosclerosis. Examples of menatetrenone derivatives are 2-methyl-3[(2E,6E,10E)-3,7,11,15- tetramethyl-2,6,10,14-hexadeca-tetraenyl]naphthoquinone and 2-methyl-3-[(2 E)-3,7,11,15-tetra-methyl-2-hexadecaenyl]naphthoquinone. The ctlinical dose of the menatetrenone derivative is 1-2,000 mg/day/adult, which is given orally, intravenously, intramuscularly, rectally or percutaneously.


Inventors:
Seeds bell meal
Application Number:
JP10450795A
Publication Date:
December 20, 2006
Filing Date:
April 28, 1995
Export Citation:
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Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
A61K31/12; A61K31/122; A61P3/02; A61P9/10; C07C50/14; (IPC1-7): A61K31/12; A61K31/12; //C07C50/14
Domestic Patent References:
JP56154433A
JP61044840A
JP52130922A
JP5051346A
JP58055416A
Other References:
LA TENEUR DES VITAMINES E, K ET C DANS LE SERUM SANGUIN DES MALADES AVEC ATHEROSCLEROSE,KARDIOLOGIJA,1974年,Vol.14, No.9,pages 130-131
化学大辞典 7 縮刷版,1987年,第30刷,第411頁-第412頁
THE MERCK INDEX,1989年,ELEVENTH EDITION,第1580-1581頁
Attorney, Agent or Firm:
Yoshiyuki Inaba
Katsuro Tanaka
Shinji Oga