Title:
抗癌剤
Document Type and Number:
Japanese Patent JP5161434
Kind Code:
B2
Abstract:
To provide an anti-cancer agent having a ferrocene skeleton and containing a phosphine transition metal complex.
This phosphine transition metal complex has a ferrocene skeleton represented by general formula (3), and this anticancer agent contains the complex.
COPYRIGHT: (C)2008,JPO&INPIT
More Like This:
Inventors:
Hiroaki Kodama
Keisuke Owata
Nobuhiko Ohara
Nakahiro Kazuhiro
Yoshio Kaneda
Keisuke Owata
Nobuhiko Ohara
Nakahiro Kazuhiro
Yoshio Kaneda
Application Number:
JP2006140878A
Publication Date:
March 13, 2013
Filing Date:
May 19, 2006
Export Citation:
Assignee:
Nippon Chemical Industry Co., Ltd.
International Classes:
A61P35/00; A61K31/66; A61P35/02; A61P35/04; C07F17/02; A61K31/28; A61K33/24; A61K33/26; C07F1/08; C07F1/10; C07F1/12; C07F15/00; C07F19/00
Domestic Patent References:
| JP2006510584A | ||||
| JP6009672A |
Other References:
SCARCIA,V. et al.,Cytostatic activity of copper(II) and copper(I) complexes towards Eagle's KB cell line,Inorganica Chimica Acta,1997年,Vol.254, No.1,p.199-200
PILLONI,G. et al.,Synthesis and solution state of [(μ-dppf)(Cu(dppf))2]X2 (dppf=1,1'-bis(diphenylphosphino)ferrocene; X=ClO4-, BF4-),Inorganica Chimica Acta,1991年,Vol.190,p.165-167
CHALONER,P.A. et al and BROADWOOD-STRONG,G.T.L.,Unexpected substitution reactions of bis(phosphine)platinum ethene complexes,Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry,1996年,No.6,p.1039-1043
LONG,N.J. et al.,Synthesis and characterization of 1-(diphenylphosphino)-1'- (methylsulfanyl)ferrocene and a series of metal (CuI, AgI)-ferrocenylene complexes,Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry,1999年,No.12,p.1981-1986
LU,X.L. et al.,Supramolecular structures in [Ag(dppf)] complexes [dppf = 1,1'-bis(diphenylphosphanyl)ferrocene] stabilized by coordinatively versatile trifluoroacetate (TFA) ligands,European Journal of Inorganic Chemistry,2004年,No.12,p.2504-2513
CALHORDA,M.J. et al.,Gold(I)-Gold(III) Interactions in Polynuclear Sulfur-Centered Complexes. Synthesis and Structural Characterization of [S(Au2dppf){Au(C6F5)3}] and [{S(Au2dppf)}2{Au(C6F5)2}]OTf (dppf = 1,1'-Bis(diphenylphosphino)ferrocene),Organometallics,1997年,Vol.16, No.17,p.3837-3844
CANALES,F. et al.,Aurophilicity at Sulfur Centers. Synthesis and Reactivity of the Complex [S(Au2dppf)]; Formation of Polynuclear Sulfur-Centered Complexes. Crystal Structures of [S(Au2dppf)]?2CHCl3, [(μ-Au2dppf){S(Au2dppf)}2](OTf)2?8CHCl3, and [S(AuPPh2Me)2(Au2dppf)](ClO4)2?3CH2Cl2,Journal of the American Chemical Society,1996年,Vol.118, No.20,p.4839-4845
TOGNI,A. et al.,Enantioselective synthesis: catalysis of the aldol reaction by neutral gold(I)-chiral ferrocenylphosphine complexes. Crystal structure of the complex [[(η5-C5H4PPh2)(η5- C5H3(PPh2)CH(Me)N(Me)CH2CH2NMe2)Fe]2(AuCl)3]?Et2O,Journal of Organometallic Chemistry,1990年,Vol.381, No.1,p.C21-C25
HOULTON,A. et al.,Studies on gold(I) complexes of 1,1'-bis(diphenylphosphino)ferrocene,Journal of Organometallic Chemistry,1991年,Vol.418, No.2,p.269-275
LI,Z. et al.,Heterometallic multinuclear Pt-M (M = Au, Ag) structural assemblies from dinuclear [Pt2(P-P)2(μ-S)2] (P-P = 2PPh3, dppf),Journal of Organometallic Chemistry,2003年,Vol.682, No.1-2,p.73-78
AL-ALLAF,T.A. et al.,Carboxylation of (DPPF)-MCl2 [DPPF = 1,1'-bis(diphenylphosphino)ferrocene; M = Pt or Pd] in aqueous and non-aqueous solution. Crystal and molecular structures of [Pt(C2O4)(DPPF)] and of [PtCl(NO3)(DPPF)],Journal of Organometallic Chemistry,2003年,Vol.678, No.1-2,p.48-55
DIEZ,J. et al.,Copper(I) complexes containing 1,1'-bis(diphenylphosphino)ferrocene (dppf) as a chelate ligand. X-ray crystal structures of [Cu2(μ-Cl)2(κ2-P,P-dppf)2] and [Cu(CNtBu)2(κ2-P,P-dppf)][BF4],Journal of Organometallic Chemistry,2001年,Vol.637-639,p.677-682
BJELOSEVIC,H. et al.,Synthesis and structural characterisation of novel platinum-based drug candidates with extended functionality by incorporation of bis(diphenylphosphino)ferrocene units as metal chelators,Tetrahedron,2006年,Vol.62, No.18,p.4519-4527
VIOTTE,M. et al.,New Iron(II)- and Gold(I)-Containing Metallocenes. X-ray Structure of a Three-Coordinate Gold(I) Ferrocenophane-Type Representative,Inorganic Chemistry,1995年,Vol.34, No.13,p.3465-3473
PILLONI,G. et al.,Synthesis and solution state of [(μ-dppf)(Cu(dppf))2]X2 (dppf=1,1'-bis(diphenylphosphino)ferrocene; X=ClO4-, BF4-),Inorganica Chimica Acta,1991年,Vol.190,p.165-167
CHALONER,P.A. et al and BROADWOOD-STRONG,G.T.L.,Unexpected substitution reactions of bis(phosphine)platinum ethene complexes,Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry,1996年,No.6,p.1039-1043
LONG,N.J. et al.,Synthesis and characterization of 1-(diphenylphosphino)-1'- (methylsulfanyl)ferrocene and a series of metal (CuI, AgI)-ferrocenylene complexes,Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry,1999年,No.12,p.1981-1986
LU,X.L. et al.,Supramolecular structures in [Ag(dppf)] complexes [dppf = 1,1'-bis(diphenylphosphanyl)ferrocene] stabilized by coordinatively versatile trifluoroacetate (TFA) ligands,European Journal of Inorganic Chemistry,2004年,No.12,p.2504-2513
CALHORDA,M.J. et al.,Gold(I)-Gold(III) Interactions in Polynuclear Sulfur-Centered Complexes. Synthesis and Structural Characterization of [S(Au2dppf){Au(C6F5)3}] and [{S(Au2dppf)}2{Au(C6F5)2}]OTf (dppf = 1,1'-Bis(diphenylphosphino)ferrocene),Organometallics,1997年,Vol.16, No.17,p.3837-3844
CANALES,F. et al.,Aurophilicity at Sulfur Centers. Synthesis and Reactivity of the Complex [S(Au2dppf)]; Formation of Polynuclear Sulfur-Centered Complexes. Crystal Structures of [S(Au2dppf)]?2CHCl3, [(μ-Au2dppf){S(Au2dppf)}2](OTf)2?8CHCl3, and [S(AuPPh2Me)2(Au2dppf)](ClO4)2?3CH2Cl2,Journal of the American Chemical Society,1996年,Vol.118, No.20,p.4839-4845
TOGNI,A. et al.,Enantioselective synthesis: catalysis of the aldol reaction by neutral gold(I)-chiral ferrocenylphosphine complexes. Crystal structure of the complex [[(η5-C5H4PPh2)(η5- C5H3(PPh2)CH(Me)N(Me)CH2CH2NMe2)Fe]2(AuCl)3]?Et2O,Journal of Organometallic Chemistry,1990年,Vol.381, No.1,p.C21-C25
HOULTON,A. et al.,Studies on gold(I) complexes of 1,1'-bis(diphenylphosphino)ferrocene,Journal of Organometallic Chemistry,1991年,Vol.418, No.2,p.269-275
LI,Z. et al.,Heterometallic multinuclear Pt-M (M = Au, Ag) structural assemblies from dinuclear [Pt2(P-P)2(μ-S)2] (P-P = 2PPh3, dppf),Journal of Organometallic Chemistry,2003年,Vol.682, No.1-2,p.73-78
AL-ALLAF,T.A. et al.,Carboxylation of (DPPF)-MCl2 [DPPF = 1,1'-bis(diphenylphosphino)ferrocene; M = Pt or Pd] in aqueous and non-aqueous solution. Crystal and molecular structures of [Pt(C2O4)(DPPF)] and of [PtCl(NO3)(DPPF)],Journal of Organometallic Chemistry,2003年,Vol.678, No.1-2,p.48-55
DIEZ,J. et al.,Copper(I) complexes containing 1,1'-bis(diphenylphosphino)ferrocene (dppf) as a chelate ligand. X-ray crystal structures of [Cu2(μ-Cl)2(κ2-P,P-dppf)2] and [Cu(CNtBu)2(κ2-P,P-dppf)][BF4],Journal of Organometallic Chemistry,2001年,Vol.637-639,p.677-682
BJELOSEVIC,H. et al.,Synthesis and structural characterisation of novel platinum-based drug candidates with extended functionality by incorporation of bis(diphenylphosphino)ferrocene units as metal chelators,Tetrahedron,2006年,Vol.62, No.18,p.4519-4527
VIOTTE,M. et al.,New Iron(II)- and Gold(I)-Containing Metallocenes. X-ray Structure of a Three-Coordinate Gold(I) Ferrocenophane-Type Representative,Inorganic Chemistry,1995年,Vol.34, No.13,p.3465-3473
Attorney, Agent or Firm:
Tokuhiro Watanabe