Title:
抗ガン剤耐性克服剤
Document Type and Number:
Japanese Patent JP5259398
Kind Code:
B2
Abstract:
An agent comprising, as an active ingredient, a xanthine oxidase inhibitor such as 2-[3-cyano-4-(4-fluorophenoxy)phenyl]-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-[3-cyano-4-(4-fluorophenoxy)phenyl]thiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-(3-cyano-4-phenoxyphenyl)thiazolo[5,4-d]pyrimidine, TMX-67, and FYX-051, which can be used as an agent for overcoming anti-cancer agent resistance.
Inventors:
Masuji Hirano
Tomio Yamakawa
Tomohisa Ishikawa
Hikaru Saito
Tomio Yamakawa
Tomohisa Ishikawa
Hikaru Saito
Application Number:
JP2008522640A
Publication Date:
August 07, 2013
Filing Date:
June 22, 2007
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO.,LTD.
International Classes:
A61K31/519; A61K31/426; A61K31/444; A61K31/52; A61K45/00; A61P35/00; A61P43/00; C07D277/20; C07D277/56; C07D401/14; C07D473/00; C07D498/04; C07D513/04
Domestic Patent References:
| JP2005508855A | 2005-04-07 | |||
| JP2003063989A | 2003-03-05 | |||
| JP2000086511A | 2000-03-28 | |||
| JP2005508855A | 2005-04-07 | |||
| JP2003063989A | 2003-03-05 |
Foreign References:
| WO2005121153A1 | 2005-12-22 | |||
| WO2003042185A1 | 2003-05-22 | |||
| WO2004080486A1 | 2004-09-23 | |||
| WO2003064410A1 | 2003-08-07 | |||
| WO2005067546A2 | 2005-07-28 | |||
| WO2007004688A1 | 2007-01-11 | |||
| WO2005121153A1 | 2005-12-22 | |||
| WO2003042185A1 | 2003-05-22 | |||
| WO2004080486A1 | 2004-09-23 | |||
| WO2003064410A1 | 2003-08-07 | |||
| WO2005067546A2 | 2005-07-28 | |||
| WO2007004688A1 | 2007-01-11 |
Other References:
JPN6012068867; ＴＡＫＡＲＡ， Ｋｏｈｊｉ ｅｔ ａｌ．: 'Ｃｙｔｏｔｏｘｉｃ ｅｆｆｅｃｔｓ ｏｆ ２７ ａｎｔｉｃａｎｃｅｒ ｄｒｕｇｓ ｉｎ ＨｅＬａ ａｎｄ ＭＤＲ１-ｏｖｅｒｅｘｐｒｅｓｓｉｎｇ ｄｅｒｉｖａｔｉｖｅ ｃｅｌｌ ｌｉｎｅｓ' Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ ｖｏｌ．２５， ｎｏ．６, 20020601, ｐ．７７１-７７８
JPN6012068867; ＴＡＫＡＲＡ， Ｋｏｈｊｉ ｅｔ ａｌ．: 'Ｃｙｔｏｔｏｘｉｃ ｅｆｆｅｃｔｓ ｏｆ ２７ ａｎｔｉｃａｎｃｅｒ ｄｒｕｇｓ ｉｎ ＨｅＬａ ａｎｄ ＭＤＲ１-ｏｖｅｒｅｘｐｒｅｓｓｉｎｇ ｄｅｒｉｖａｔｉｖｅ ｃｅｌｌ ｌｉｎｅｓ' Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ ｖｏｌ．２５， ｎｏ．６, 20020601, ｐ．７７１-７７８
JPN6012068867; ＴＡＫＡＲＡ， Ｋｏｈｊｉ ｅｔ ａｌ．: 'Ｃｙｔｏｔｏｘｉｃ ｅｆｆｅｃｔｓ ｏｆ ２７ ａｎｔｉｃａｎｃｅｒ ｄｒｕｇｓ ｉｎ ＨｅＬａ ａｎｄ ＭＤＲ１-ｏｖｅｒｅｘｐｒｅｓｓｉｎｇ ｄｅｒｉｖａｔｉｖｅ ｃｅｌｌ ｌｉｎｅｓ' Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ ｖｏｌ．２５， ｎｏ．６, 20020601, ｐ．７７１-７７８
Attorney, Agent or Firm:
Chikusa Shinichi