Title:
抗Ｂ型肝炎性ポリ及びオリゴヌクレオチド
Document Type and Number:
Japanese Patent JPH09511382
Kind Code:
A
Abstract:
Poly- and oligonucleotides which inhibit viral replication, particularly hepatitis virus replication, such as hepatitis B virus (HBV) replication, are disclosed. Preferred antiviral oligonucleotides include the following: an antiviral poly- or oligonucleotide which hybridizes to at least a portion of an RNA primer-binding region of a viral nucleic acid, preferably a DRII region of HBV DNA; an antiviral poly- or oligonucleotide which hybridizes to at least a portion of an RNA primer which binds a viral nucleic acid, preferably a DRII region of HBV DNA; an antiviral poly- or oligonucleotide which hybridizes to a hepatitis virus mRNA encoding a DNA polymerase, preferably an HBV mRNA; an antiviral poly- or oligonucleotide which hybridizes to a hepatitis virus mRNA encoding an envelope protein essential for viral attachment to a target cell, preferably an HBV mRNA encoding a pre-S1 protein; and an antiviral poly- or oligonucleotide which hybridizes to an encapsidation signal of a viral nucleic acid, preferably an HBV cis-encapsidation signal, thereby inhibiting encapsidation of the viral nucleic acid. The disclosed poly- or oligonucleotides can be used for detection of the presence of viral nucleic acid, particularly HBV DNA, in a cell and can be used to treat viral infection in a subject.
Inventors:
カーマイケル，エレン
Application Number:
JP51914695A
Publication Date:
November 18, 1997
Filing Date:
January 11, 1995
Export Citation:
Assignee:
ターゲテック インコーポレイテッド
International Classes:
A61K38/00; A61K47/48; A61K48/00; A61P1/16; A61P31/12; C07H21/04; C12N15/00; C12N15/09; C12N15/113; G01N33/566; G01N33/576; C12R1/92; (IPC1-7): C12N15/09; A61K38/00; A61K47/48; A61K48/00; C07H21/04; G01N33/566; G01N33/576
Attorney, Agent or Firm:
倉内 基弘 （外１名）