ANTI-NGF ANTIBODIES AND METHOD USING SAME

Title:

ANTI-NGF ANTIBODIES AND METHOD USING SAME

Document Type and Number:

Japanese Patent JP2008148710

Kind Code:

A

Abstract:

To provide anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same, for the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

The invention relates to the anti-nerve growth factor (NGF) antibody wherein the antibody, (a) binds NGF with a KD of less than about 2 nM, (b) inhibits human NGF-dependent survival of mouse E13.5 trigeminal neurons with an IC50 of about 100 pM or less, wherein the IC50 is measured in the presence of about 15 pM human NGF, and (c) inhibits human NGF-dependent survival of mouse E13.5 trigeminal neurons with an IC50 of about 10 pM or less, wherein the IC50 is measured in the presence of about 1.5 pM of human NGF.

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Inventors:

SHELTON DAVID L
PONS JAUME
ROSENTHAL ARNON

Application Number:

JP2008007312A

Publication Date:

July 03, 2008

Filing Date:

January 16, 2008

Export Citation:

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Assignee:

RINAT NEUROSCIENCE CORP

International Classes:

C12N15/09; A61P29/00; C07K16/22; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; A61K39/395; C12P21/08

Domestic Patent References:

JPH06510671A

1994-12-01

Other References:

HYBRIDOMA, (2000), 19, [3], P.215-227, JPN6008006990, ISSN: 0000991436
BIOTECHNOLOGY, (1992), 10, [7], P.779-783, JPN6008006994, ISSN: 0000991437
PROC. NATL. ACAD. SCI. USA, (1994), 91, [9], P.3809-3813, JPN6008006999, ISSN: 0000991438
GENE, (1996), 169, [2], P.147-155, JPN6008007005, ISSN: 0000991439
J. IMMUNOL., (1995), 155, [4], P.1994-2004, JPN6008007011, ISSN: 0000991440
J. IMMUNOL., (1995), 154, [7], P.3310-3319, JPN6008007019, ISSN: 0000991441
J. MOL. BIOL., (1992), 226, [3], P.889-896, JPN6008007084, ISSN: 0000991442
IMMUNOL. TODAY, (1993), 14, [6], P.243-246, JPN6008055244, ISSN: 0001169666
J. MOL. BIOL., (1992), 224, [2], P.487-499, JPN6008055243, ISSN: 0001169665

Attorney, Agent or Firm:

Yoshinobu Murofushi

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