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Title:
ANTI-OSTEOPOROSIS AGENT
Document Type and Number:
Japanese Patent JPH07215849
Kind Code:
A
Abstract:

PURPOSE: To obtain an anti-osteoporosis agent having a suppressive function against osteoclast formation and excellent in activity and safety by compounding a polyisoprenoide derivative as an effective component.

CONSTITUTION: This agent contains a compound of formula I (R is OH, formula II or formula III; waved line is an E-type or a Z-type double bond), e.g. (2E,6E,10 E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraene-1-ol. The agent may be formulated into a preparation, e.g. a powder, a particle, a granule, a tablet, a coated tablet, a capsule, an ointment, a plaster or an injection. A daily dose for an adult is 100-3000mg. The compound of formula I has the suppressive activity against osteoclast formation in a coexistent system of an osteoblast and a spleen cell. In osteoporosis, the balance between bone resorption and osteogenesis is destroyed and the bone resorption is accelerated. As a result, the amount of bone is decreased, bones become fragile and pain is accompanied. Osteoporosis frequently occurs especially in a postmenopausal woman and its treatment continues for a long time. Therefore, the danger of the occurrence of side effects characteristic to female sex hormones is concerned and so as drug is required to have high safety.


Inventors:
Hara, Kuniko
Akiyama, Yasuhiro
Nakamura, Tetsuya
Application Number:
JP1994000024956
Publication Date:
August 15, 1995
Filing Date:
January 28, 1994
Export Citation:
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Assignee:
EISAI CO LTD
International Classes:
A61K31/045; A61K31/12; A61P19/10; A61P43/00; C07C33/02; C07C50/14; C07C50/32; (IPC1-7): A61K31/12; A61K31/045