ANTI-PD-1 ANTIBODIES AND METHODS OF USE THEREOF

Title:

ANTI-PD-1 ANTIBODIES AND METHODS OF USE THEREOF

Document Type and Number:

Japanese Patent JP2023053114

Kind Code:

A

Abstract:

To provide therapeutic agents designed to antagonize PD-1 signaling, the therapeutic agents capable of holding great promise for treatment of diseases that involve PD-1 -mediated immune suppression, given the role of human PD-1 in modulating immune responses.SOLUTION: The disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.SELECTED DRAWING: None

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Inventors:

Marc van Dyke
Anne Cornelia Mont
Gerd Ritter
David Jed Walchok
Taha Mergoub
Roberta Zappa Zodi
Baek Ricke Holmguard
David Skaer
Adam David Savitzky
Stuart Nicholas Wilson

Application Number:

JP2023018480A

Publication Date:

April 12, 2023

Filing Date:

February 09, 2023

Export Citation:

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Assignee:

Agenus Incorporated
Ludwig Institute for Cancer Research RTD
Memorial Sloan Kettering Cancer Center

International Classes:

C12N15/13; A61K39/395; A61P31/00; A61P35/00; A61P35/02; A61P37/04; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/0783; C12N5/10; C12N15/63; C12P21/02; C12P21/08

Attorney, Agent or Firm:

Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe

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