Title:
ANTI-T CELL ANTIGEN BINDING MOLECULES FOR USE IN COMBINATION WITH ANGIOGENESIS INHIBITORS
Document Type and Number:
Japanese Patent JP2023078311
Kind Code:
A
Abstract:
To provide compositions and methods for the prevention, alleviation, or treatment of cytokine release or side effects due to cytokine release associated with administration of an anti-T Cell antigen-binding molecule to a subject.SOLUTION: Provided is a pharmaceutical composition containing an anti-T cell antigen-binding molecule, the pharmaceutical composition being characterized in that it is used in combination with a vascular epithelial cell growth factor (VEGF) inhibitor, the anti-T cell antigen-binding molecule comprising: (1) a domain containing an antibody variable region having CD3 binding activity; and (2) a domain containing an antibody variable region having glypican 3-binding activity, and the VEGF inhibitor being selected from the group consisting of bevacizumab, ramucirumab, and aflibercept.SELECTED DRAWING: Figure 2-A
Inventors:
TANAKA TAKAYOSHI
SANO YUJI
KAWAI YUMIKO
SANO YUJI
KAWAI YUMIKO
Application Number:
JP2023043678A
Publication Date:
June 06, 2023
Filing Date:
March 20, 2023
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
A61K39/395; A61K31/56; A61K31/573; A61P35/00; A61P37/02; A61P43/00; C07K14/705; C07K16/00; C07K16/24; C07K16/28; C07K19/00; C12N15/12; C12N15/13; C12N15/62
Attorney, Agent or Firm:
Masao Haruna
Hatsushi Shimizu
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Kousuke Umemura
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Maki Shioda
Kazuya Kawamoto
Hatsushi Shimizu
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Kousuke Umemura
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Maki Shioda
Kazuya Kawamoto