Title:
リボヌクレオチドレダクターゼのR1およびR2成分に対して指向される抗腫瘍アンチセンス配列
Document Type and Number:
Japanese Patent JP4301576
Kind Code:
B2
Abstract:
A synthetic antisense oligonucleotide comprising at least seven nucleotides or nucleotide analogues having a sequence complementary to the mRNA sequence of ribonucleotide reductase dimeric protein component R2 including SEQ ID Nos:1-102 is disclosed. A synthetic antisense oligonucleotide comprising at least seven nucleotides or nucleotide analogues having a sequence complementary to the mRNA sequence of ribonucleotide reductase dimeric protein component R1 including SEQ ID Nos:103-161 is also disclosed. The invention also discloses pharmaceutical compositions including the synthetic antisense oligonucleotides of the present invention and methods of using the antisense oligonucleotides to modulation proliferative cells including neoplastic cells.
Inventors:
Light, Jim A.
Young, Apin H.
Young, Apin H.
Application Number:
JP50741098A
Publication Date:
July 22, 2009
Filing Date:
August 01, 1997
Export Citation:
Assignee:
Laurus Therapeutics, Inc.
International Classes:
C12N15/09; A61K31/7088; A61P35/00; C12N9/02; C12N15/113; C12Q1/68; A61K38/00
Domestic Patent References:
| JP2000513230A |
Other References:
Cancer Chemother. Pharmacol., 1994年, vol.34, p.63-66
, Biochemistry, 1995年, vol.34, p.5411-5418
DNA Sequence, 1992年, vol.2, p.227-234
Proc. Natl. Acad. Sci. USA, 1996年, vol.93, p.514-518
Enzyme, 1990年, vol.44, p.106-119
, Biochemistry, 1995年, vol.34, p.5411-5418
DNA Sequence, 1992年, vol.2, p.227-234
Proc. Natl. Acad. Sci. USA, 1996年, vol.93, p.514-518
Enzyme, 1990年, vol.44, p.106-119
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita