ANTIBACTERIAL COMPOSITION AND PRESCRIPTION

Title:

ANTIBACTERIAL COMPOSITION AND PRESCRIPTION

Document Type and Number:

Japanese Patent JP2012229254

Kind Code:

A

Abstract:

To provide a molecule small enough to be synthesized without need of transforming a living organism with a nucleic acid encoding the corresponding peptide, and presenting to the living body various different methods of administration, the molecule is bioactive, especially antibacterial, concretely anti-bacillus.

The invention includes: a use of a molecule containing a main chain having 2-35 non-hydrogen atoms concerning the chain length, having at least two bulky oleophilic groups shared-coupling to the main chain, and having cationic groups at least one more than anionic groups, when a medical agent is produced for instabilizing cell membrane of microorganisms; and a use of a molecule containing a main chain having 2-35 non-hydrogen atoms concerning the chain length, having one ultra-bulky oleophilic group containing at least nine non-hydrogen atoms, and cationic groups at least two more than anionic groups, as a membrane-acting antibacterial agent; and specifically a peptide including a peptide derivative and peptide-like substance.

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Inventors:

SVENDSEN JOHN SIGURD
HAUG BENGT ERIK
MARKO ISTVAN
REKDAL OEYSTEIN
SKAR MERETE LINCHAUSEN
STENSEN WENCHE
STROEM MORTEN BOEHMER

Application Number:

JP2012158714A

Publication Date:

November 22, 2012

Filing Date:

July 17, 2012

Export Citation:

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Assignee:

LYTIX BIOPHARMA AS

International Classes:

A61K38/00; A61K38/08; A61K45/00; A61K47/06; A61K47/48; A61P31/04; A61P35/00; C07K5/06; C07K5/068; C07K5/072; C07K5/078; C07K5/09; C07K5/097; C07K5/11; C07K5/117; C07K7/06

Domestic Patent References:

JPH0578392A	1993-03-30
JPH05148295A	1993-06-15
JPH05148296A	1993-06-15
JPH05148297A	1993-06-15
JPH0578392A	1993-03-30
JPH05148295A	1993-06-15
JPH05148296A	1993-06-15
JPH05148297A	1993-06-15

Foreign References:

WO1999059616A1	1999-11-25
US6143795A	2000-11-07
US5885782A	1999-03-23
WO1999059616A1	1999-11-25
US6143795A	2000-11-07
US5885782A	1999-03-23

Other References:

JPN6011006196; ＨＡＧＥＮ，　Ｅ．Ａ．　ｅｔ　ａｌ．: Ａｃｔａ　Ｃｈｅｍｉｃａ　Ｓｃａｎｄｉｎａｖｉｃａ　ＢＶｏｌ．３８, 1984, ｐｐ．５-１４
JPN6011006198; ＨＡＭＭＡＭ，　Ａ．Ｓ．　ｅｔ　ａｌ．: Ｉｎｄｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　ＣｈｅｍｉｓｔｒｙＶｏｌ．２１Ｂ, 1982, ｐｐ．３４８-３５１
JPN6011006199; ＢＯＧＥＲ，　Ｄ．Ｌ．　ｅｔ　ａｌ．: Ｊ．　Ｏｒｇ．　Ｃｈｅｍ．Ｖｏｌ．６４, 1999, ｐｐ．７０-８０
JPN6011006200; ＲＥＮＡＵ，　Ｔ．Ｅ．　ｅｔ　ａｌ．: Ｊ．　Ｍｅｄ．　Ｃｈｅｍ．Ｖｏｌ．４２, 1999, ｐｐ．４９２８-４９３１
JPN6011006203; ＳＰＡＴＯＬＡ，　Ａ．Ｆ．　ｅｔ　ａｌ．: Ｐｅｐｔｉｄｅｓ　ｆｏｒ　ｔｈｅ　Ｎｅｗ　Ｍｉｌｌｅｎｎｉｕｍ，　Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｐｅｐｔｉｄｅ　Ｓｙｍｐｏｓｉｕｍ , 1999, ｐｐ．７３８-７３９
JPN6011006206; ＭＯＬＩＮＥＲＯ，　Ｊ．　ｅｔ　ａｌ．: ＰｅｐｔｉｄｅｓＶｏｌ．１９９０, 1990, ｐｐ．４３６-４３７
JPN6011006207; ＮＥＤＥＶ，　Ｈ．Ｎ．　ｅｔ　ａｌ．: Ｄｏｋｌａｄｙ　Ｂｏｌｇａｒｓｋｏｉ　Ａｋａｄｅｍｉｉ　ＮａｕｋＶｏｌ．４２, 1989, ｐｐ．３１-３４
JPN6011006196; ＨＡＧＥＮ，　Ｅ．Ａ．　ｅｔ　ａｌ．: Ａｃｔａ　Ｃｈｅｍｉｃａ　Ｓｃａｎｄｉｎａｖｉｃａ　ＢＶｏｌ．３８, 1984, ｐｐ．５-１４
JPN6011006198; ＨＡＭＭＡＭ，　Ａ．Ｓ．　ｅｔ　ａｌ．: Ｉｎｄｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　ＣｈｅｍｉｓｔｒｙＶｏｌ．２１Ｂ, 1982, ｐｐ．３４８-３５１
JPN6011006199; ＢＯＧＥＲ，　Ｄ．Ｌ．　ｅｔ　ａｌ．: Ｊ．　Ｏｒｇ．　Ｃｈｅｍ．Ｖｏｌ．６４, 1999, ｐｐ．７０-８０
JPN6011006200; ＲＥＮＡＵ，　Ｔ．Ｅ．　ｅｔ　ａｌ．: Ｊ．　Ｍｅｄ．　Ｃｈｅｍ．Ｖｏｌ．４２, 1999, ｐｐ．４９２８-４９３１
JPN6011006203; ＳＰＡＴＯＬＡ，　Ａ．Ｆ．　ｅｔ　ａｌ．: Ｐｅｐｔｉｄｅｓ　ｆｏｒ　ｔｈｅ　Ｎｅｗ　Ｍｉｌｌｅｎｎｉｕｍ，　Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｐｅｐｔｉｄｅ　Ｓｙｍｐｏｓｉｕｍ , 1999, ｐｐ．７３８-７３９
JPN6011006206; ＭＯＬＩＮＥＲＯ，　Ｊ．　ｅｔ　ａｌ．: ＰｅｐｔｉｄｅｓＶｏｌ．１９９０, 1990, ｐｐ．４３６-４３７
JPN6011006207; ＮＥＤＥＶ，　Ｈ．Ｎ．　ｅｔ　ａｌ．: Ｄｏｋｌａｄｙ　Ｂｏｌｇａｒｓｋｏｉ　Ａｋａｄｅｍｉｉ　ＮａｕｋＶｏｌ．４２, 1989, ｐｐ．３１-３４

Attorney, Agent or Firm:

Patent corporation ssinpat

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