PURPOSE: To provide a new compd. having antimicrobial activity which is useful for the treatment for microbial infection.
CONSTITUTION: This compd. is expressed by formula I (wherein, R1 is H, 1-6C alkyl; (n) is 0 to 2; R3 is H, 1-6C alkyl; R2 is 1-6C alkyl, cyano, -CONH2, -CH2OH, -CH2NH2, etc), for example, (4R,5S,6S)-6-[1'(R)-hydroxyethyl]-4- methyl-3-[[[(5-methyl-1,3,4-oxadiazol-2-yl)thio]methyl]thio]-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid. The compd. expressed by formula I is obtd. by allowing a compd. expressed by formula II (wherein M+ is a metal cation or H) to react with an alkylating agent expressed by formula III (wherein Q is a deprotective group such as iodine) in the presence of an amine base such as trialkylamine to obtain a compd., then eliminating a protecting group of the obtd. compd. by hydrolysis with an enzyme, and then oxidizing sulfur to form a sulfinyl or sulfonyl group.
KIYARORU BACHIYANDO
JIYANNPOORU DARISU
