ANTIBIOTIC KO-3988A AND KO-3988B AND PRODUCTION THEREOF

Title:

ANTIBIOTIC KO-3988A AND KO-3988B AND PRODUCTION THEREOF

Document Type and Number:

Japanese Patent JPH02191291

Kind Code:

A

Abstract:

NEW MATERIAL:Antibiotic KO-3988A having the following physical and chemical properties. Element composition: C22H26O7 (high resolving power mass spectrometry). Molecular weight: 402 [field desorption(FD) mass spectrometry]. Melting point: 182-183°C. Specific rotatory power: [α] =-46° (C=0.58, chloroform). Solubility: insoluble in hexane and water and soluble in methanol, ethanol, dichloromethane, chloroform, ethyl acetate, butyl acetate and acetone. Neutral substance. Color reaction: positive in sulfuric acid, and iodine coloring.

USE: A multiplication inhibitor against HeLa cell not showing antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.

PREPARATION: A bacterium such as Streptomyces KO-3988 (FERM P-10369) belonging to the genus Streptomyces, capable of producing antibiotic KO-3988A is cultured under an aerobic condition at 27°C for 3-6 days.

Inventors:

OMURA SATOSHI
KOMIYAMA HIROKI
FUNAYAMA SHINJI

Application Number:

JP959689A

Publication Date:

July 27, 1990

Filing Date:

January 18, 1989

Export Citation:

Click for automatic bibliography generation Help

Assignee:

KITASATO INST

International Classes:

C12P1/06; A61K35/74; A61P31/04; C07G11/00; C12R1/465; (IPC1-7): A61K35/74; C07G11/00; C12P1/06

Attorney, Agent or Firm:

Takehiko Suzue (3 outside)

Previous Patent: COBALT COMPLEX AND PRODUCTION OF HYDROXYL GROUP-CONTAINING COMPOUND USING THE COMPLEX

Next Patent: PRODUCTION OF ACTEOSIDE