ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR B-CELL MATURATION ANTIGEN

Title:

ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR B-CELL MATURATION ANTIGEN

Document Type and Number:

Japanese Patent JP2023082109

Kind Code:

A

Abstract:

To provide improved BCMA-binding molecules, and to provide engineered BCMA-targeting cells.SOLUTION: Provided herein are BCMA-binding molecules, e.g., anti-BCMA antibodies and antigen-binding fragments thereof such as heavy chain variable (VH) regions and single-chain antibody fragments; and chimeric receptors comprising the anti-BCMA binding molecules, such as chimeric antigen receptors (CARs). In some embodiments, the anti-BCMA antibodies or antigen-binding fragments thereof specifically bind to BCMA-1. Among others, the anti-BCMA antibodies are human antibodies, e.g., those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs or BCMA-binding molecules and uses thereof such as in adoptive cell therapy.SELECTED DRAWING: None

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Inventors:

BLYTHE D SATHER
STEVEN M SHAMAH
CHEN YAN
REBECCA WU
COLLIN HAUSKINS
CSABA PAZMANY
JUI DUTTA-SIMMONS
KIMBERLY HARRINGTON

Application Number:

JP2023055046A

Publication Date:

June 13, 2023

Filing Date:

March 30, 2023

Export Citation:

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Assignee:

JUNO THERAPEUTICS INC

International Classes:

C12N15/13; A61K35/12; A61K35/17; A61K38/17; A61K39/395; A61K47/68; A61P1/04; A61P3/10; A61P5/16; A61P7/04; A61P7/06; A61P9/14; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P21/04; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P43/00; C07K14/725; C07K16/28; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/0783; C12N5/10; C12N15/12; C12N15/62; C12N15/63; C12N15/867

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto

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