Title:
変形抗体を含む抗体−薬物接合体
Document Type and Number:
Japanese Patent JP6708751
Kind Code:
B2
Abstract:
The present invention relates to: an antibody-drug conjugate in which a modified antibody, containing a motif of a specific structure at an end of the antibody, is coupled to a drug through a linker; and a composition containing the same and, specifically, to: a modified antibody-drug conjugate (mADC) comprising a modified antibody coupled to the C-terminus of heavy chain or light chain so as to have a remarkably increased drug conjugation yield; and a composition containing the same.
Inventors:
Park, Songchee
Chung, Hyo Shin
Lee, Sonpe
Byun, Minsu
Chung, Hyo Shin
Lee, Sonpe
Byun, Minsu
Application Number:
JP2018552180A
Publication Date:
June 10, 2020
Filing Date:
March 30, 2017
Export Citation:
Assignee:
Arteogen Incorporated
International Classes:
C07K19/00; A61K31/16; A61K31/18; A61K31/4745; A61K31/519; A61K31/537; A61K31/704; A61K31/7048; A61K31/7064; A61K38/08; A61K39/395; A61K47/55; A61K47/68; A61P35/00; A61P43/00; C07K7/06; C07K16/18
Domestic Patent References:
| JP2015513541A |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama