Title:
CD148の血管形成阻害ドメインの抗体
Document Type and Number:
Japanese Patent JP2007534694
Kind Code:
A
Abstract:
Anti-CD148 antibodies and antigen-binding regions thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding regions, are described. Also described are methods of using such antibodies and antigen-binding regions to bind CD148 epitopes and activate CD148 function, such as inhibition of angiogenesis. Epitopes that can be used to activate CD148 function and anti-angiogenesis activity are also described, as well as methods of identifying compounds that can bind them.
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Inventors:
Fanslow, William Sea, The Third
Caribbean, Revital
James F, The Smithers
Caribbean, Revital
James F, The Smithers
Application Number:
JP2007509713A
Publication Date:
November 29, 2007
Filing Date:
April 22, 2005
Export Citation:
Assignee:
Amgen Incorporated
International Classes:
C07K16/28; A01K67/027; A61K39/395; A61P9/00; A61P9/10; A61P11/06; A61P15/00; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P35/04; C07K14/705; C07K16/30; C12N5/10; G01N33/53
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho