Title:
ANTIBODIES SPECIFIC FOR CADHERIN-17
Document Type and Number:
Japanese Patent JP2016047835
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide antibodies against Cadherin-17, nucleic acids encoding the antibodies and therapeutic proteins, methods for preparing the anti-Cadherin-17 antibodies and methods for treating Cadherin-17 mediated diseases such as human cancer including colorectal cancer.SOLUTION: The invention provides isolated antibodies, including monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, expression vectors including the nucleic acid, host cells including the nucleic acid and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.SELECTED DRAWING: Figure 35A-B
Inventors:
CHRISTIAN ROHLFF
JONATHAN ALEXANDER TERRETT
JONATHAN ALEXANDER TERRETT
Application Number:
JP2015215376A
Publication Date:
April 07, 2016
Filing Date:
November 02, 2015
Export Citation:
Assignee:
OXFORD BIOTHERAPEUTICS LTD
International Classes:
C07K16/28; A61K38/00; A61K39/395; A61K45/00; A61K51/00; A61P35/00; C07K16/18; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12P21/08
Domestic Patent References:
| JP2005500034A | 2005-01-06 |
Other References:
CANCER SCIENCE, vol. 94, no. 5, JPN5012012220, May 2003 (2003-05-01), pages 425 - 430, ISSN: 0003395826
"ANTI-HUMAN CADHERIN-17 ANTIBODY", INTERNET R&D SYSTEMS CATALOG [ONLINE], JPN5012012216, 22 September 2004 (2004-09-22), pages 1 - 1, ISSN: 0003395827
"DATASHEET: MCA2998Z, MOUSE ANTI HUMAN CADHERIN-17 ANTIBODY", ABD SEROTEC CATALOG [ONLINE], JPN5012012218, 1 December 2007 (2007-12-01), pages 1 - 2, ISSN: 0003395828
MODERN PATHOLOGY, vol. 21, JPN6016033660, 2008, pages 1379 - 1386, ISSN: 0003395829
"ANTI-HUMAN CADHERIN-17 ANTIBODY", INTERNET R&D SYSTEMS CATALOG [ONLINE], JPN5012012216, 22 September 2004 (2004-09-22), pages 1 - 1, ISSN: 0003395827
"DATASHEET: MCA2998Z, MOUSE ANTI HUMAN CADHERIN-17 ANTIBODY", ABD SEROTEC CATALOG [ONLINE], JPN5012012218, 1 December 2007 (2007-12-01), pages 1 - 2, ISSN: 0003395828
MODERN PATHOLOGY, vol. 21, JPN6016033660, 2008, pages 1379 - 1386, ISSN: 0003395829
Attorney, Agent or Firm:
Toru Ishikawa