Title:
破骨細胞関連タンパク質を標的とした抗体
Document Type and Number:
Japanese Patent JP5078104
Kind Code:
B2
Abstract:
The present invention relates to a method of detecting metabolic bone disorders using a gene expressed at a high level in osteoclasts, a method of screening for a compound effective for treatment and/or prevention of metabolic bone disorders, and a pharmaceutical composition for treatment and/or prevention of metabolic bone disorders. Specifically, the present invention relates to a method of detecting metabolic bone disorders using expression of the human DC-STAMP gene as an indicator, a pharmaceutical composition containing an antibody which is capable of specifically recognizing human DC-STAMP and suppressing formation of osteoclasts, and so forth.
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Inventors:
Naomi Nomiyama
Toshio Kukita
Daytime Yoshiharu
Toshio Kukita
Daytime Yoshiharu
Application Number:
JP2010231331A
Publication Date:
November 21, 2012
Filing Date:
October 14, 2010
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
A61K39/395; A61K48/00; A61P3/14; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P35/00; C07K16/28; C12N15/09; C12P21/08; C12Q1/68; G01N33/15; G01N33/50; G01N33/53
Foreign References:
| WO2001036463A1 |
Other References:
Eur.J.Immunol.,2000年,Vol.30,p.3585-3590
DNA and Cell Biology,2002年,Vol.21,p.541-549
DNA and Cell Biology,2002年,Vol.21,p.541-549
Attorney, Agent or Firm:
Kimiki Ishibashi
Toshiaki Yaguchi
Noriko Kitano
Imamura Mayu
Yukiko Nakamura
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara
Toshiaki Yaguchi
Noriko Kitano
Imamura Mayu
Yukiko Nakamura
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara