Title:
新規甲状腺癌関連抗原に結合する抗体および甲状腺癌診断剤
Document Type and Number:
Japanese Patent JP6793514
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide early detection of thyroid cancer with blood samples by identifying a thyroid cancer-associated antigen present in the blood of thyroid cancer patients in a soluble form using an antibody that specifically bind to the antigen.SOLUTION: A thyroid cancer-associated antigen was isolated from the blood of a thyroid cancer patient and identified as a fibronectin with an N-linked sugar chain of which apparent molecular weight is about 250 KDa as determined by SDS-PAGE. We confirmed that, by using an antibody or antigen-binding fragment thereof that specifically binds to the thyroid cancer-associated antigen, thyroid cancer can be diagnosed with a blood sample.SELECTED DRAWING: Figure 2
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Inventors:
Hiroshi Takeyama
Makoto Yoshinobu
Michiko Watanabe
Tetsuo Hosoya
Makoto Yoshinobu
Michiko Watanabe
Tetsuo Hosoya
Application Number:
JP2016199730A
Publication Date:
December 02, 2020
Filing Date:
October 11, 2016
Export Citation:
Assignee:
Hiroshi Takeyama
Makoto Yoshinobu
Michiko Watanabe
Makoto Yoshinobu
Michiko Watanabe
International Classes:
C07K16/30; C12N15/11; G01N33/53; G01N33/574
Domestic Patent References:
| JP2007061063A |
Other References:
武山浩,甲状腺癌乳頭癌転移巣におけるアイソトープ集積増加をめざした、甲状腺モノクローナル抗体JT-95と131Iの結合物質(JT-95-131I)による選択的分子標的治療の試み,癌の臨床,日本,篠原出版新社,2004年10月,第50巻第10号,825ページ~830ページ
Attorney, Agent or Firm:
Asako Sudo
Akinobu Sudo
Eriko Suzuki
Akinobu Sudo
Eriko Suzuki