Title:
ホスホリパーゼA2に対する抗体及びその使用
Document Type and Number:
Japanese Patent JP2006517188
Kind Code:
A
Abstract:
The invention described herein relates to antibodies directed to the antigen phospholipase A2 (PLA2) and uses of such antibodies. In particular, in accordance with some embodiments of the invention, there are provided fully human monoclonal antibodies directed to the antigen PLA2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
Inventors:
Gregory M. Landes
Marie Hark-Frencho
Ring chain
Yen-War Rosanne Lee
Meina El Leang
Guio Feng
Guio-Ji Jia
Mark Earl Noselini
Marie Hark-Frencho
Ring chain
Yen-War Rosanne Lee
Meina El Leang
Guio Feng
Guio-Ji Jia
Mark Earl Noselini
Application Number:
JP2004557469A
Publication Date:
July 20, 2006
Filing Date:
December 02, 2003
Export Citation:
Assignee:
Abgenics Incorporated
Rexicon Genetics Incorporated
Rexicon Genetics Incorporated
International Classes:
C07K16/40; A61K39/395; A61P9/08; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P25/28; C07K17/00; G01N33/573; C12N15/09; C12P21/08
Domestic Patent References:
| JPH06510912A | 1994-12-08 | |||
| JPH0436193A | 1992-02-06 |
Foreign References:
| WO2000076310A1 | 2000-12-21 |
Other References:
JPN6009054000, Ｂｉｏｃｈｅｍ． Ｂｉｏｐｈｙｓ． Ｒｅｓ． Ｃｏｍｍｕｎ．, 19900330, Ｖｏｌ．１６７， Ｎｏ．３, ｐｐ．１３０９−１３１５
JPN6009053999, Ｎａｔ． Ｇｅｎｅｔ．, 199702, Ｖｏｌ．１５， Ｎｏ．２, ｐｐ．１４６−１５６
JPN6009053999, Ｎａｔ． Ｇｅｎｅｔ．, 199702, Ｖｏｌ．１５， Ｎｏ．２, ｐｐ．１４６−１５６
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro