Title:
ANTIBODIES TO RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF
Document Type and Number:
Japanese Patent JP2016104740
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide antibodies, particularly monoclonal antibodies capable of being used in the treatment and diagnosis of Alzheimer's disease (AD), central nervous system cell degeneration, learning and memory impairment, abnormal transport of amyloid β, and other neurological inflammatory symptoms associated with a receptor for advanced-glycation-end-products (RAGE).SOLUTION: The invention provides isolated monoclonal antibodies with an antigen binding domain which can bind to the epitope of a human RAGE molecule, or a RAGE molecular binding fragment thereof, wherein the antigen binding domain is a heavy chain variable (VH) region and a light chain variable (VL) region.SELECTED DRAWING: None
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Inventors:
GU JIJIE
HSIEH CHUNG-MING
WU ZHEN
ENRICO L DIGIAMMARINO
LUO FENG
GERARD B FOX
JOHN E HARLAN
SCHMIDT MARTIN
RALF LOEBBERT
REINHOLD MUELLER
EBERT ULRICH
VOLKER NIMMRICH
HSIEH CHUNG-MING
WU ZHEN
ENRICO L DIGIAMMARINO
LUO FENG
GERARD B FOX
JOHN E HARLAN
SCHMIDT MARTIN
RALF LOEBBERT
REINHOLD MUELLER
EBERT ULRICH
VOLKER NIMMRICH
Application Number:
JP2015235370A
Publication Date:
June 09, 2016
Filing Date:
December 02, 2015
Export Citation:
Assignee:
ABBVIE DEUTSCHLAND
ABBVIE INC
ABBVIE INC
International Classes:
C07K16/28; A61K39/395; A61P13/12; A61P19/02; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/06; A61P29/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12P21/08
Foreign References:
| WO2006077101A2 | 2006-07-27 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office