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Title:
ANTIBODY-AGENT CONJUGATE HAVING HIGH AGENT LOADS
Document Type and Number:
Japanese Patent JP2015209426
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing antibody-agent conjugate having high agent loads, and to provide a method of use.SOLUTION: A transglutaminase-mediated antibody-agent conjugate having high agent-antibody ratio (DAR) contains 1) endogenous glutamine which is made reactive by engineering glutamine-containing tag, endogenous glutamine, and/or antibody or engineered transglutaminase (e.g., by change of substrate specificity); and 2) an amine donor substance containing an amine donor unit, a linker, and an active substance part; wherein DAR is at least about 5.

Inventors:
PAVEL STROP
KATHERINE ANNE DELARIA
MAGDALENA DORYWALSKA
DAVIDE LUCIANO FOLETTI
RUSSELL GEORGE DUSHIN
DAVID LOUIS SHELTON
ARVIND RAJPAL
Application Number:
JP2015088055A
Publication Date:
November 24, 2015
Filing Date:
April 23, 2015
Export Citation:
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Assignee:
RINAT NEUROSCIENCE CORP
PFIZER
International Classes:
C07K16/00; A61K39/395; A61P35/00; C12P21/02; C12P21/08; G01N33/574
Domestic Patent References:
JP2014500868A2014-01-16
JP2014500866A2014-01-16
JP2016532684A2016-10-20
JP2016528183A2016-09-15
Foreign References:
US20130122020A12013-05-16
WO2013092983A22013-06-27
Other References:
CHEMISTRY & BIOLOGY, 2013, VOL.20, PP.161-167, JPN6019011761, ISSN: 0004232963
PLOS ONE, 2013, VOL.8, NO.4, E60350, JPN6019011763, ISSN: 0004232964
Attorney, Agent or Firm:
Noh four
Junko Miyazawa
Maki Sato
Tatsuta Miyuki



 
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