Title:
158P1D7タンパク質に結合する抗体薬物結合体(ADC)
Document Type and Number:
Japanese Patent JP6426607
Kind Code:
B2
Abstract:
The invention provides an antibody-drug conjugate comprising an anti-158P1D7 antibody or antigen binding fragment thereof conjugated to monomethyl auristatin E (MMAE), wherein the antibody or fragment thereof comprises a heavy chain variable region comprising an amino acid sequence at least 80% homologous to the heavy chain variable region amino acid sequence set forth in SEQ ID NO:7 and a light chain variable region comprising an amino acid sequence at least 80% homologous to the light chain variable region amino acid sequence set forth in SEQ ID NO:8.
Inventors:
Morrison Robert Kendall
Anjiri
Morris Karen Jane Meyrick
Snyder Josh
Chia Xiao
Anjiri
Morris Karen Jane Meyrick
Snyder Josh
Chia Xiao
Application Number:
JP2015528704A
Publication Date:
November 21, 2018
Filing Date:
August 23, 2013
Export Citation:
Assignee:
Agensis, Inc.
Seattle Genetics, Inc.
Seattle Genetics, Inc.
International Classes:
C07K19/00; A61K39/395; A61K45/00; A61K47/42; A61P35/00; A61P43/00; C07K16/18; C07K16/46; C12N5/10; C12N15/13; C12N15/63; C12P21/08
Domestic Patent References:
| JP2007524361A | ||||
| JP2007514652A |
Foreign References:
| US20030017466 | ||||
| US20030207835 | ||||
| US20030199470 |
Other References:
Molecular Cancer Therapeutics,2004年,Vol.3, No.8,p.921-932
Nature Biotechnology,2008年,Vol.26, No.8,p.925-932
Nature Biotechnology,2008年,Vol.26, No.8,p.925-932
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto