Title:
抗癌タンパク質-白金コンジュゲート
Document Type and Number:
Japanese Patent JP2012516330
Kind Code:
A
Abstract:
The invention provides polypeptide-platinum conjugates comprising an anti-cancer platinum complex conjugated to polypeptides that bind relatively specifically to cancer cells, so as to direct the conjugates to cancer cells resulting in increased anti-cancer efficacy and decreased side-effects as compared to cisplatin and other conventional anti-cancer platinum complexes.
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Inventors:
Mactabish, Hugh
Application Number:
JP2011547980A
Publication Date:
July 19, 2012
Filing Date:
January 29, 2010
Export Citation:
Assignee:
IG F Oncology LLC
International Classes:
C07C55/22; A61K38/00; A61P35/00; C07K14/475; C07K14/485; A61K38/28; C07F15/00; C07K14/71; C07K14/72
Domestic Patent References:
| JP2008502585A | 2008-01-31 | |||
| JPH02795A | 1990-01-05 | |||
| JP2001500133A | 2001-01-09 | |||
| JPS54154718A | 1979-12-06 | |||
| JPH08510750A | 1996-11-12 | |||
| JPH05500218A | 1993-01-21 | |||
| JPS61222927A | 1986-10-03 |
Foreign References:
| WO1999001462A1 | 1999-01-14 |
Other References:
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JOURNAL OF CONTROLLED RELEASE, vol. １３１（２）, JPN6014010850, 2008, pages 100 - 106, ISSN: 0002767370
BIOCONJUGATE CHEM, vol. １５, JPN6014010851, 2004, pages 814 - 823, ISSN: 0002767371
JOURNAL OF MASS SPECTROMETRY, vol. ４１（８）, JPN6014010854, 2006, pages 1061 - 1072, ISSN: 0002767375
INORGANICA CHIMICA ACTA, vol. ９３, JPN6014010858, 1984, pages 167 - 172, ISSN: 0002767372
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, vol. ３５（８）, JPN6014010853, 2003, pages 327 - 333, ISSN: 0002767373
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, vol. ７, JPN6014010859, 1983, pages 912 - 916, ISSN: 0002767374
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Katsuichi Nishimoto
Kato Kazunori
Katsuichi Nishimoto