Title:
ANTIDIABETIC ENOLIC GLUCOSIDE OF PHENYLPYRUVIC ACID
Document Type and Number:
Japanese Patent JP2018087233
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an antidiabetic enolic glucoside of phenylpyruvic acid and derivatives thereof, for use as medicaments, especially normoglycemic agents, i.e. for lowering blood glucose levels to normal levels in mammals that are obese, pre-diabetic or have diabetes, obesity and/or syndrome X.SOLUTION: Compounds of the present invention help to manage blood glucose levels, i.e. helping the body by balancing the blood glucose levels; helping to keep balanced blood glucose levels, particularly in humans with diabetes; aiding by enhancing the glucose uptake by the cells and by reducing blood glucose levels, thus improving or restoring the glucose tolerance; optimizing the glycemic response; and normalizing the glucose tolerance.SELECTED DRAWING: None
Inventors:
ELIZABETH JOUBERT
STEPHEN JOHN FEY
JOHAN LOUW
TROND ULVEN
RAHUL TYAGI
STEPHEN JOHN FEY
JOHAN LOUW
TROND ULVEN
RAHUL TYAGI
Application Number:
JP2018028462A
Publication Date:
June 07, 2018
Filing Date:
February 21, 2018
Export Citation:
Assignee:
ZADEC APS
International Classes:
C07H15/18; A61K31/7028; A61K31/7042; A61P3/04; A61P3/10; A61P43/00; C07H15/26
Domestic Patent References:
| JP2010520913A | 2010-06-17 |
Other References:
MARAIS C.: "THE OCCURRENCE OF PHENYLPYRUVIC ACID IN WOODY PLANTS: BIOSYNTHETIC SIGNIFICANCE", TETRAHEDRON LETTERS, vol. 37, no. 32, JPN5014000296, 5 August 1996 (1996-08-05), NL, pages 5763 - 5764, XP004030532, DOI: doi:10.1016/0040-4039(96)01178-1
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TETRAHEDRON, vol. Vol.46(2), JPN6014044696, 1990, pages 383 - 394
PHYTOCHEMISTRY, vol. Vol.55(1), JPN6014044685, 2000, pages 67 - 75
CHEMICAL & PHARMACEUTICAL BULLETIN, vol. Vol.56(11), JPN6014044686, 2008, pages 1546 - 1550
SUGIMOTO TAKANORI: "BIOMIMETIC SYNTHESIS OF A LEAF-OPENING FACTOR, POTASSIUM ISOLESPEDEZATE, 以下備考", CHEMISTRY LETTERS, vol. 33, no. 8, JPN5014000294, 1 January 2004 (2004-01-01), JP, pages 976 - 977, XP009146180, DOI: doi:10.1246/cl.2004.976
TETRAHEDRON LETTERS, vol. Vol.43(37), JPN6014044687, 2002, pages 6529 - 6532
PHYTOCHEMISTRY, vol. p.65(8), JPN6014044688, 2004, pages 1117 - 1121
CHEMICAL & PHARMACEUTICAL BULLETIN, vol. Vol.48(11), JPN6014044689, 2000, pages 1768 - 1770
TETRAHEDRON LETTERS, vol. Vol.40(19), JPN6014044690, 1999, pages 3757 - 3760
TETRAHEDRON LETTERS, vol. Vol.41(18), JPN6014044691, 2000, pages 3433 - 3436
TETRAHEDRON LETTERS, vol. Vol.48(13), JPN6014044692, 2007, pages 2409 - 2413
TETRAHEDRON, vol. Vol.59(31), JPN6014044693, 2003, pages 5909 - 5917
TETRAHEDRON LETTERS, vol. Vol.43(42), JPN6014044694, 2002, pages 7545 - 7548
TETRAHEDRON, vol. Vol.55(36), JPN6014044695, 1999, pages 10925 - 10936
TETRAHEDRON, vol. Vol.46(2), JPN6014044696, 1990, pages 383 - 394
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Miki Nakamura
Hironobu Onda
Atsushi Honda
Miki Nakamura