Title:
ANTIFUNGAL AGENT CONTAINING TOLNAFTATE
Document Type and Number:
Japanese Patent JP3259972
Kind Code:
B2
Abstract:
PURPOSE: To obtain an antifungal agent, containing tolnaftate and salicylic acid, capable of remarkably enhancing percutaneous absorbability and skin storage of the tolnaftate, having powerful antimicrobial activity and excellent in stability, safety and feeling of use.
CONSTITUTION: The objective an antifungal agent is obtained by adding ≥10%, preferably 10-20% salicylic acid to tolnaftate which is a principal agent, dissolving or suspending the resultant mixture in a usually used solvent such as ethanol or purified water, as necessary, blending a stabilizer, preservative, etc., therewith and further, as necessary, blending other medicinally active ingredients such as an antifungal agent or an antiinflammatory and analgesic agent, a surfactant, alcohols, a solvent, a viscosity increasing agent, etc., and preparing a pharmaceutical such as a cream, an ointment, a gel, etc. When the antifungal agent is used as a medicine for external use, the agent can be used as salts such as sodium salt without any serious side effects and pains, etc.
Inventors:
Tatsumi Nakajima
Hiroshi Fujita
Takashi Nagai
Kenichi Inagaki
Hiroshi Fujita
Takashi Nagai
Kenichi Inagaki
Application Number:
JP33939791A
Publication Date:
February 25, 2002
Filing Date:
November 29, 1991
Export Citation:
Assignee:
Zeria Shinyaku Kogyo Co., Ltd.
Toyo Farmer Co., Ltd.
Toyo Farmer Co., Ltd.
International Classes:
A61K9/06; A61K9/08; A61K31/27; A61K31/60; A61K47/12; A61P17/00; A61P31/10; (IPC1-7): A61K31/27; A61K47/12; A61P31/10
Domestic Patent References:
| JP57146711A | ||||
| JP2204413A |
Other References:
【文献】国際公開93/5776(WO,A1)