Title:
ANTIFUNGAL AGENT AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP3691856
Kind Code:
B2
Abstract:
PURPOSE: To obtain a compound useful as an antifungal agent effective for therapy of dermatomycosis, visceral mycosis, etc.
CONSTITUTION: This compound is represented by the formula (A is =CH-or =N-; L and M are H, a halogen; R1 is a five-membered heterocycle or a condensed ring), or its acid adduct, e.g. 1-(2,4-difluorophenyl)-1-[4-(2,4-difluorophenyl- thiazol-2-yl]-2-(1H-1,2,4-triazol-1-yl)ethanol. This compound can be synthesized by reacting 4-(2,4-difluoro-phenyl)thiazole with 2-chloro-2',4'-difluoroacetophenone in the presence of n-butyllithium and subsequently adding and reacting 1,2,4- triazole and sodium hydride therewith.
Inventors:
Toshihiko Naito
Katsura
Yumiko Karai
Takashi Tsukada
Toyozawa Itsu
Katsura
Yumiko Karai
Takashi Tsukada
Toyozawa Itsu
Application Number:
JP3326894A
Publication Date:
September 07, 2005
Filing Date:
February 07, 1994
Export Citation:
Assignee:
EISAI CO.,LTD.
International Classes:
C07D409/06; A61K31/41; A61K31/415; A61K31/425; A61K31/495; A61K31/535; A61K31/54; A61P17/00; A61P31/04; A61P31/10; C07D417/06; C07D417/14; C07D495/04; C07D497/04; C07D498/02; C07D513/04; A61K31/426; A61K; C07D; (IPC1-7): C07D417/06; C07D417/14
Domestic Patent References:
| JP1149780A | ||||
| JP1132583A | ||||
| JP60224689A | ||||
| JP5770885A |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Katsuro Tanaka
Shinji Oga
Katsuro Tanaka
Shinji Oga