Title:
ANTIFUNGAL TRIAZOL COMPOUND
Document Type and Number:
Japanese Patent JPH1180135
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To obtain a new triazol compound or a pharmacologically acceptable salt thereof, showing an excellent antifungal activities against various fungi, and useful as a medicine, especially an active ingredient for an antifungal agent because of small toxicity. SOLUTION: This triazol compound is a compound of formula I [Ar<1> is phenyl; Ar<2> is phenyl, naphthyl, a 5- or 6-membered aromatic heterocycle, a condensed bicyclic aromatic heterocycle or the like; R<1> and R<2> are each H or an alkyl; (p) is 0-3; (q) and (r) are each 0-2; A is formula II, formula III or the like] or a pharmacologically acceptable salt thereof, e.g. 2-(2,4- difluorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-[2-[4[trifluorome thyl)phenyl]-1,3- dioxan-5-yl]-2-butanol. The compound of formula I is obtained by reacting an alcohol and/or a thiol compound of formula IV with an aldehyde compound of formula V.
Inventors:
KONOSU TOSHIYUKI
UCHIDA TAKUYA
OIDA SADAO
YASUDA HIROSHI
UCHIDA TAKUYA
OIDA SADAO
YASUDA HIROSHI
Application Number:
JP19223198A
Publication Date:
March 26, 1999
Filing Date:
July 08, 1998
Export Citation:
Assignee:
SANKYO CO
International Classes:
C07D249/08; A61K31/41; A61P31/04; A61P31/10; C07D405/06; C07D409/06; C07D411/06; (IPC1-7): C07D249/08; A61K31/41; C07D405/06; C07D409/06; C07D411/06
Attorney, Agent or Firm:
Akio Ohno (2 outside)
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