Title:
複数の生理活性を有する抗原の消失を促進する抗原結合分子
Document Type and Number:
Japanese Patent JP7149306
Kind Code:
B2
Abstract:
The present inventors newly discovered that even if an antigen-binding molecule inhibits in vitro some of the physiological activities of an antigen having two or more physiological activities without inhibiting the remaining physiological activities, the molecule can promote elimination of the antigen from blood (from serum or plasma) and as a result reduce the physiological activities in vivo, when the antigen-binding molecule is conferred with the properties: (i) of binding to human FcRn under an acidic pH range condition; (ii) of binding under a neutral pH range condition to human Fc receptor stronger than native human IgG, and (iii) that its antigen-binding activity alters according to the ion concentration.
Inventors:
Tomoyuki Ikawa
Atsuhiko Maeda
Shigeo Tamba
Takehisa Kitazawa
Takeshi Baba
Ruike Keinao
Junichi Nezu
Atsuhiko Maeda
Shigeo Tamba
Takehisa Kitazawa
Takeshi Baba
Ruike Keinao
Junichi Nezu
Application Number:
JP2020062236A
Publication Date:
October 06, 2022
Filing Date:
March 31, 2020
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07K16/28; C07K16/18; C12N15/13; C12P21/08
Domestic Patent References:
| JP2008519860A |
Foreign References:
| WO2009125825A1 | ||||
| WO2011122011A2 | ||||
| WO2010106180A2 |
Other References:
J.Immunol.,2009年,Vol.182,p.7663-7671
Nat.Biotechnol.,2010年,Vol. 28,p. 1203-1207
BIO INDUSTRY,2011年06月,Vol.28,No.7,p.15-21
J.Immunol.,2010年,Vol.184,p.1968-1976
Nat.Biotechnol.,2010年,Vol.28,No.2,p.157-159
Nat.Biotechnol.,2010年,Vol. 28,p. 1203-1207
BIO INDUSTRY,2011年06月,Vol.28,No.7,p.15-21
J.Immunol.,2010年,Vol.184,p.1968-1976
Nat.Biotechnol.,2010年,Vol.28,No.2,p.157-159
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto