Title:
ANTIMICROBIAL MEDICINE
Document Type and Number:
Japanese Patent JP2903292
Kind Code:
B2
Abstract:
PURPOSE: To obtain an N1-(1,2-cis-2-halogenocyclopropyl) substituted pyridonecarboxylic acid derivative useful as a medicine for human bodies, animals and fishes, an agrochemical or a preservative for foods, having strongly antimicrobial action.
CONSTITUTION: This antimicrobial agent comprises a compound of the formula [R1 is H, amino, OH or SH which may contain a substituent group; R2 is a cyclic amino (may contain further N, O or S in the ring) which may contain a substituent group; A is a C-X3 (X3 is a halogen, a 1-6C alkyl, a 1-6C alkoxy, CF3 or H); X1 and X2 each is a halogen; Z is H, a 1-alkyl, a 1-6C alkoxyalkyl, a phenyl-1-6C alkyl, phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyloxy, choline, diaminomethyl, 5-indanyl, phthalidinyl, etc.] or its salt such as 7-[3-(S)-amino-1-pyrrolidinyl]-6-fluoro-1-(1,2-cis-2- fluorocyclopropyl)-4-oxo-1,4-dihydroxyquinoline-3-carboxylic acid as an active ingredient.
Inventors:
HAYAKAWA ISAO
KIMURA YOICHI
KIMURA YOICHI
Application Number:
JP8828295A
Publication Date:
June 07, 1999
Filing Date:
April 13, 1995
Export Citation:
Assignee:
DAIICHI SEIYAKU KK
International Classes:
A61K31/00; A61K31/435; A61K31/4375; A61K31/44; A61K31/455; A61K31/47; A61K31/4709; A61K31/495; A61K31/55; A61P31/00; A61P31/04; C07D213/61; C07D215/233; C07D215/56; C07D401/04; C07D405/14; C07D471/04; C07D519/00; C07D; (IPC1-7): A61K31/47; A61K31/495; A61K31/55
Domestic Patent References:
| JP2231475A | ||||
| JP61218575A | ||||
| JP6212760A | ||||
| JP62187459A | ||||
| JP63201170A | ||||
| JP62226962A |
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)
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